"Amphotericin B": ako, te huarahi o te mahi. Mua e pā ana ki te tarukino

kiri fungal kawea nui hūhi ki te manawanui. Ano, taua mate hopuhopu. Na reira, ka me tika kōrero i te tohu tuatahi o te harore ki te mātanga. I muri haere nga whakamātautau hauora, me te tahi atu whakamātautau takoto te tākuta kei te ki te whakarite i te manawanui drugs whai hua.

Tino maha, mo te maimoatanga o te mate fungal te whakamahi i te whānuitanga o hinu me pire. Heoi, te nuinga o taote mea e te pai tukinotia te taua huru pathological i werohia rō-uaua. I muri werohanga o te tarukino timata tonu ki te mahi i runga i microorganisms e whakaatu he tūtohutanga ngā ki reira.

Ko te ara tino pai, me te whai hua ki te kawe rongoā ki te whakakore mate fungal "Amphotericin B". E te aroaro Tohutohu, puka o tuku me mua e pā ana ki te tarukino i raro.

Puka, hanganga, whakaahuatanga me te tākai o paturopi

Whiwhi whakaaro te tarukino e taea e i roto i te puka e whai ake nei:

• Lyophilisate "Amphotericin B". Kua korerotia Reviews e tenei ahua o te tarukino ko te papatipu hygroscopic maiengi o te tae kōwhai ki kahore he kakara korerotia. Kei te hangaia te reira mo te faaineineraa o te otinga whaowhia. Ko te wāhanga kaha o te tarukino he amphotericin B. e whakamahia te wāhanga rite matū pŭpŭ tauturu pērā i monobasic Phosphate konutai me te waikawa deoxycholic. I roto i te hoko o te medicament tukua e i roto i oko o te 10 ml, me kātene pepa.

• Hinu "Amphotericin B". whakaaturia Taupānga o tenei tikanga te rite te tarukino tāpiri i roto i ngā therapy. hinu antifungal whakamahia waho anake. He kōwhai reira me kei te whakauru kaha o te taua ingoa. Ko nga wae atu e kua whakamahia rite te hinu kohuke, petrolatum, me polysorbate 80. Hokona taea tenei rongoā e i roto i te pouaka o 30 '15 ranei

Ko te tikanga o te mahi o te protivogribkvogo tarukino

He aha te mea te tarukino "Amphotericin B"? (Kitea papa ki te whakauru hohe taua rawa raruraru) Tohutohu mō te whakamahi pūrongo e ko te reira i te rongoā paturopi polyene macrocyclic ki mahi antifungal. Kei te whakaputaina te reira e Streptomyces nodosus, ka whakarato fungistatic me mahi fungicidal (i runga i te kukū o te tarukino i roto i fluids koiora me te susceptibility rānei).

I muri i te tarukino tomo te awa toto herea reira ki sterols e kua kitea i roto i te kiriuhi pūtau o te harore tairongo ki te tarukino. Ka rite ki te hua o taua te rongo ohorere te uruhanga me te tango i ngā wae intracellular puta i roto i te wāhi wahopūtau.

Ko te tarukino ko "amphotericin B" he kaha ki taumahatanga maha, me te kaha tika ki harore hātare.

Me mahara hoki käore te reira e e tenei tikanga ātete spp Fusarium. a boydii Pseudallescheria. I roto i te tua, e kore he whai hua ki rickettsiae, huakita me wheori tenei tarukino.

Ko te āhuatanga konikoni o te tarukino

Na e matau ana koutou e he taua he kaihoko antifungal, rite "Amphotericin B". Kua te tikanga o te mahi o tenei kaihoko kua whakaahuatia ana i runga.

I muri i whakahaere rō-uaua o te raau taero i roto i te horopeta kotahi i roto i te toto i hanga tonu tona kukū whai hua tonu nei puta noa i te ra. pūmua C herea ki te wē taputapu e 90 ōrau.

tohaina medicament tirohia i roto i te ate, pūkahukahu, tākihi, kōateate, uaua, repe adrenal me ētahi atu okana me te kopa. Ko tōna kukū i roto i te effusion pleural, peritoneal me fluids synovial me te arearea wai tae 2/3 o te kukū i roto i te toto.

tikanga mōhiotia tēnei ara. I roto i te mimi me te ate e pā ana ki 98 ōrau o te hakari tarukino i roto i te puka o metabolites. āta whakaaturia i roto i nga whatukuhu. Ko te tuatahi hawhe-ora o te tarukino i roto i ngā pakeke, ko te 24 haora, i roto i te tamariki - 6-40 haora, me te hou - 20-60 haora. Kāpeka hawhe-te ora ko te 15 ra.

Tuhinga rongoā paturopi

E akono mate rongoā "Amphotericin B"? I whakaritea e ia i roto i ahu whakamua, mate fungal ora-te whakawehi i meinga e microorganisms haria:

• histoplasmosis, cryptococcosis ueue, coccidioidomycosis;
• meningitis cryptococcal, paracoccidioidomycosis, chromomycosis;
• meningitis meinga e te tahi atu harore, Te Tai Tokerau blastomycosis American;
• metastatic me aspergillosis urutomo, phycomycosis (zygomycosis);
• hanga gialogifomikoza candidiasis tohatohaina;
• mycosis pokepokea ai, mycetoma ma'i;
• sporotrichosis tohatohaina, mate puku (tae atu peritonitis);
• endophthalmitis, endocarditis, sepsis fungal;
• leishmaniasis visceral, fungal mate mimi;
• American leishmaniasis visceral waihakihaki.

Contraindications kaihoko antifungal

Fakakaukau ki he me'a kāwanatanga ki te tono i te tarukino rāhuitia "Amphotericin B" (papa i te harore o te taua ingoa e kore e hua). E ai ki nga tohutohu, contraindicated te tenei taputapu:

• täkihi ma'i;
• i roto i te hypersensitivity;
• i roto i te whāngai ū.

Ki te tiaki medicament kaha whakamahia i roto i te mate tākihi (tae atu glomerulonephritis), amyloidosis, ate cirrhosis, kakā, anemia, agranulocytosis, hapūtanga me te mate huka.

Lyophilisate "Amphotericin B": tohutohu mō te whakamahi

Hoki te faaineineraa o te otinga rongoā rō-uaua i whakamahia ki te kukū tuatahi o 5 mg / ml. Na roto i te pūwero ki te 10 ml o te wai horomata mō te werohanga kia te pounamu ki te medicament. Next, te tirotiro whakangaueuetia ki te hanga i te inu colloidal mārama.

whakahaere tarukino rō-uaua i roto i te haora i raro i te mana o te pēhanga toto, te pāmahana tinana me te auau ngakau o te manawanui. I roto i tona raau kātakí pai i inenga rā o 0.25-0.3 mg ia taimaha tinana kg tūtohutia (i runga i te pakeke o te mate).

I roto i mate o te ngakau, me oko toto, nui haere tūtohutanga me te mahi tākihi iti, tīmataria maimoatanga te ki toketaá iti (5-10 mg), āta te nei nui haere e 5-10 mg ia ra, me te te whakaritea ki te 0.5-0.7 mg ia kg.

A, no te sporotrichosis rongoā horopeta akoranga ko 2.5 g, me te roanga o te therapy - mo te iti rawa 9 marama.

A, no te te inenga taputapu aspergillosis ko 3.6 g, me te roanga o te maimoatanga - i te iti rawa 11 marama.

Pēpi i te timatanga o te therapy whakahaerea 0,25 mg ia taimaha tinana kg ia ra, me te ka nui haere āta ki te horopeta mōrahi (1 mg ia kg).

Hinu "Amphotericin B": tohutohu mō te whakamahi

e kore e Papa i raro i te ingoa hokohoko taua i roto i pharmacies hokona. Na reira, hoki te whakakapinga o tenei rongoā kia kōrero te tākuta.

Ki te whakamahi tika i te hinu kei te tono "Amphotericin B" kahu angiangi ki te wāhi kua pā rua rā. Tei te akoranga maimoatanga i runga i te taunakitanga e wātea ana:

• ki candidiasis o nga hipi kiri - e pā ana ki 1-3 wiki;
• ki ponana kope i roto i ngā tamariki - āhua 7-14 ra;
• ki paronychia me ngā wāhi interdigital patu - 2-4 wiki.

pānga taha

Te faaineineraa "Amphotericin B" kia meinga i te pānga taha e whai ake nei:

• pāhoahoa, hukihuki, neuropathy piringa, te taninito tūao, encephalopathy;
• mate o te hiahia, ruaki, dyspepsia, whakapairuaki, gastralgia, korere, hepatotoxicity, kore ate whakapeka, jaundice, kakā, melena, köpiro haemorrhagic;
• anemia normochromic normocytic, leukopenia, whakararuraru upoo-, thrombocytopenia, agranulocytosis, anemia hemolytic, eosinophilia, leukocytosis;
• kite te peroo, rongo mate, diplopia, tinnitus;
• tachypnea, dyspnea, edema pūkahukahu, arrhythmia me te hypersensitivity pneumonitis;
• te heke haere ranei nui haere te pēhanga toto, apohia e, huringa i roto i tawhā ECG, kore ngakau, ru, kore ngakau;
• tauhohe anaphylactoid, te tihe, nephrogenic mate huka insipidus, bronchospasm, nephrocalcinosis, hikaka, dermatitis eksfoliativiy, paitini necrolysis epidermal
• täkihi, hypokalemia, gipostenuriyu, tākihi acidosis tubular, Stevens - Johnson syndrome, täkihi whakapeka, oliguria, anuria;
• thrombophlebitis me tahu i te wāhi i werohia;
• kirika, myalgia, mate taimaha, arthralgia, ngoikore whānui.

take o te tuwhena rawa

A, no te whakahaere pota nui o rongoā kia mutu i te manawanui manawa me te ngakau. Na reira, i roto i te akoranga o te therapy kia tino piri ki te tākuta inenga tūtohutia. Ko reira tika hoki ki te aroturuki i te romahā me cardiac, tākihi me te ate mahi, piringa pikitia toto, me te tona ihirangi o electrolytes.

Hototahi ki ētahi atu rongoa

Ko te medicament "Amphotericin B" taea faananea ranei attenuate te pānga o ētahi atu raau taero, me te ki ake i to ratou tāoke. Na reira, whakaritea tenei raau e ki tūpato i roto i te maimoatanga.

I roto i te whakarite o te kaihoko mea ki te manawanui, kia tino ki te whakamōhio i tō tākuta e pā ana ki te tango i ētahi atu taero. Kore, kia tuukino ki te hauora, me te whānui oranga o te tangata te whakamahi o "Amphotericin B" (rō-uaua).

tūtohutanga motuhake

• Ko te tarukino ko "amphotericin B" ka te whakamahi anake mo te maimoatanga o te ora-te whakawehi, me te fungal ahu whakamua mate.
• Ki te whakamahi roa o te tūponotanga o piki pānga paitini.
• A, no te kia te whakamahi o te raau taero anemia faahope.

Reviews

Na e matau ana koutou e founga te tarukino mahi "Amphotericin B". E kore te mea te whakatārewatanga ki te taua ingoa i runga i te hoko i roto i pharmacies. Na reira, mo te whakahaere-waha, kia whiriwhiri koe tetahi tarukino ki te mahi rite.

E ai ki te nuinga o tūroro, whakaaro he tikanga ki tōtika akakoromaki ki te mahi. Kei te tino hamani te reira i pāpaka kiri fungal, te whakakore hūhi tinana, me te hinengaro o te manawanui.

Ko te drawback matua o tenei tarukino ko te maha nui o ngā pānga taha. I roto i te maimoatanga, kia puta tenei taputapu tauhohe kino i runga i te wahi o okana me ngā pūnaha katoa. Na reira, kia tono reira anake i roto i te tohu motuhake.