Ko te tarukino "Amiodarone": analogues, tohutohu, arotake

Heart, rite matau koutou, to matou tinana matua, engari reira maha kore. I roto i te tikanga ki te whakahoki tona mahi noa whakamahi i te momo o te raau taero. Ko tētahi o ratou ko "Amiodarone". He nui atu te utu Analogs, rite e hua noa atu, a he kore tonu whai hua.

Ko te hanganga o te tarukino me te ahua o

Ko te medicament "Amiodarone", e arotake te momo Kei roto i tetahi papa o 200 mg o whakauru hohe - hydrochloride amiodarone. hanga te faaineineraa te atu rite te otinga, i reira 3 ml he 5% o te whakauru kaha.

wāhanga Houalotú titoa o tetahi papa e: māngaro potato, tioata microcellulose, reihuka, maltodextrin, primelloza, polyvinylpyrrolidone, stearate konupora.

hipokina nga papa ki te pīata o te tae ma ki te iti, whakamarumaru kirīmi mohio. E ratou te ahua o Valium me te tuhaa a Valium. Na reira, ki te tika, e taea ngāwari te wehea ratou ki e rua nga wahi e rite ana.

Drug hokona i roto i ngā pouaka pepa, te wahi kotahi e rua ranei opupu ki papa kotahi tekau. Kei te hua hoki te tarukino i roto i te karaihe, polymeric me te kirihou ipu, e whai 30 ranei 100 papa.

Ko te tikanga pharmacological o mahi tarukino

E āhuatanga āhuatanga Antiarrhythmic me antianginal e "Amiodarone" analogues i roto i ētahi wā ia e taea te whakakapi. hāngai Ko tōna mahi anti-arrhythmic te i runga i te nāianei whakaiti o katote pāhare pāporo ina i raro ki ngā pūtau membrane - cardiomyocytes. ai te reira i te whakaiti i roto i te kōpuku pakohu i hanga bradycardia.

Whakamahi o te tarukino "Amiodarone" (pire) taea ake i te roa o te whakangutungutu tikanga kawenga cardiac. Inhibits te kawe ia o ngā ara tuarua i roto i te tūroro ki syndrome nui o Wolff-Parkinson-White syndrome. I roto i te tahuri, hanga te pānga tarukino antianginal te i runga i te whakaiti kohi hāora myocardial, me te whakaiti i ona pānga i runga i te uaua matua. Kei te tito o iodine, i te mea i roto i te whakamahi o te ine taui te ihirangi o te thyroid taiki, hua i roto i te tohu o to ratou pānga i runga i te myocardium te heke.

"Amiodarone" kua he katoahia, me te pānga korerotia i runga i tona tono puta i muri i anake kotahi wiki o te whakamahi auau o te raau taero, ka tae te mōrahi e i muri i rua-toru wiki.

Roto whenumi e pā ana ki 40% o inu he horopeta, puta Cmax wē i muri i 3-7 haora. Taea ki te tohe mo te rave rahi wiki te pānga ko. ngā tukanga pūkoro tango i te wahi te nuinga i roto i te ate, te wahi i hanga he huānga kaha te dezetilamiodaron, e ko te metabolite nui. Hoki ki ate huna ana, me te mimi, T1 / 2 - i muri i te horopeta kotahi o te tarukino 3,2-20,7 h, ki te therapy auroa - i muri i 53 ± 24 haora.

Medicine "Amiodarone": tohu hoki te whakamahi

Whakahau i te tarukino mo te ārai me te maimoatanga o arrhythmias, e taea ma'ie te hopohopo ora tangata, me te arrhythmias ventricular, kaka ventricular i roto i akiaki iu whakamahia hoki tarukino "Amiodarone."

tukua Tuhinga ki te whakamahi i te tarukino ki:

• kaka Atrial;
• arrhythmias supraventricular;
• Wolff-Parkinson-White syndrome;
• takanga o te tachycardia;
• fibrillyatsionnogo ventricles taea;
• arrhythmia puta tika ki iti hoki cardiac me coronary;
• momo ma'i o te mate ngakau coronary;
• infarction myocardial.

"Amiodarone": tohutohu mō te whakamahi

E te tikanga Papa mō te whakahaere ā-waha i muri i te 15 meneti i muri i te kai.

I roto i ventricular inenga mate fibrillation tūtohutia e te rata, he 800-1200 mg ia ra. kia wehea te reira ki 3-4 pōhiri. Te maimoatanga i roto i tenei take pumau hoki e pā ana ki 5-10 ra ki te whakarite kia atu ai te huru pūmau o te manawanui, a taea te tuku iho te auau ki te 600-800 mg ia ra. Tenei maimoatanga kaha, e muri puta ki ārai, he horopeta raro o te ihirangi tarukino.

wā tiaki haumanu ko 7-14 nga ra, i roto i tenei wa o te tarukino tango 200-400 mg. rōrahi tarukino taua whakaritea ki te ū huru o te manawanui i roto i te wā poslereabilitatsionny.

E mea pinepine te rongoa "Amiodarone" whakaritea ina ko te manawanui i roto i te fare ma'i, a taea ana technique whakahaere i te tākuta. hanga tenei reira taea ki te whakaiti i te pānga taha, me te takitahi whakarite te horopeta o te tarukino.

A, no te whakamahi i te angina mate medicament rua he ra i 200 mg. I muri i te rua wiki, ka heke te inenga ki kotahi te ra. E kore e te mōrahi horopeta horopeta kotahi nui 400 mg me te rā - 1200 mg.

I roto i meinga enei taero ki ngā tamariki kia whanau i roto i te ngakau e te pire pā te tamaiti, ko te nui tere atu i te pakeke. Na reira, tatau te horopeta e hāngai i runga i te taimaha o te tamaiti. Ko te kupu, me hinga tetahi manokaramu o taimaha 10 mg o medicament. Me mau tonu tenei horopeta puta noa te wā haumanu o nga ra kotahi tekau ra ano ake huru o te manawanui ranei. Ake nei, ki tenei whakatakotoranga whakaiti i te rahi o te 5 mg ia manokaramu taimaha o te tamaiti tinana. tangohia horopeta tiaki ārai te ka i runga i tetahi manokaramu o 2.4 mg o tarukino "Amiodarone."

Tuhinga ki te tarukino whakaritea ki te whakamahi i te otinga i runga i whakauru kaha o amiodarone hydrochloride i roto i arrhythmias cardiac whakapeka. I roto i tenei take, whakahaere te raau taero e pâmuhia, āta patia ki te tinana ki te dropper. Ki te mahi i tenei, 250 ml o 5% otinga kūhuka mō te 1 2 ranei i āta patia horopeta tarukino o 5 mg ia taimaha tinana kirokaramu. I tenei wa, te aroturuki i te manawanui e tikanga o ECG me pānuitanga ine pēhanga toto.

pānga taha

Na maha taero whakahaunga "Amidaron" i roto i to tatou whenua. e kore e taea e ki te whakakapi ia tonu Analogs. Otiia ahakoa nga pānga pai o te raau taero i runga i te tinana tangata, kua oti tāutuhia me nga pānga taha.

E te nuinga e tika ana ki te tuwhena rawa tarukino tohu tōraro. Tenei ofatiraa o te pūnaha Cardiovascular, pērā i bradycardia, kore mahi pakohu kōpuku, poraka ngakau, mate o ruruku o te kaupapa. Ano i runga i te wahi o te pūnaha romahā i kitea ruia ana kakakīrehe interstitial pūkahukahu, kakā interstitial, Hamm syndrome - Rich, uma mamae, kakakīrehe pūkahukahu, tachypnea, mamae bronchopulmonary. kitea kore ate i ka te fariiraa "Amidaron" faaineineraa. Papa i roto i te wā onge meinga jaundice, kakā, cirrhosis ētahi wā.

Kore ki te ū ki te inenga e taea meinga te tāne i nui o hormones thyroid, distireoza me hypothyroidism, me te huinga o toka anō. Ka taea e tuwhena rawa arahi ki te rangirua o te taputapu ataata, meinga te haaputuputuraa o lipids i roto i te taupoki io ki te tauira. Ano, i reira te mea he ähua korerotia o te kiri, photosensitivity, urticaria erythema ranei. i kitea rashes Minor mata, alopecia, dermatitis. uesia hoki pānga taha te mahi whakaputa uri i roto i nga tangata. I roto i enei take ki reira he orchitis, paruparu, me epididymitis. thrombocytopenia Tino onge, täkihi, ranei angioedema vasculitis.

Contraindications ki te whakamahi o

whiriwhiri "Amiodarone" (kihai i urupare tonu pai) Kei te tino takitahi. He iwi e kore i te āwhina tenei tarukino ranei kihai i ratou ite tino kore huringa i roto i te āhua o te hauora, ka anga etahi ki notia iho i muri i te tono koe i te reira, ua palpitations ngakau. I roto i to ratou kupu, Propafenone he reira e taea ki te whakapōrearea i te pūnaha endocrine hormones ake i. Na reira, i mua i te tango i tenei hua rongoa me kore anake āta pānui i te tohutohu, engari ano hoki e whakarongo ki nga tohu, pānga taha me contraindications.

Ko te kupu, e kore te tikanga kia tono te tarukino, ki te reira he atrioventricular poraka kōeke 2-3, i roto i te ru cardiogenic, hyperthyroidism. e kore te faaineineraa "Amiodarone" whakamahia i roto i tona tūtohutanga tiketike ki te kaihoko kaha, me te iodo. I kanga he maumaui nui o te kawenga cardiac me wāhanga o bradycardia ki syncope. Kaua e whakamahi i te tarukino i roto i te hapū, me te hohipera. Hohipera, i roto i te wā o te maimoatanga tarukino kia mutu whāngai ū.

tūtohutanga motuhake

Kia āta mātakitaki i e te rata maimoatanga whakaora tarukino "Amiodarone". Tohutohu mō te whakamahi taunaki ki te whakamahi i nga papa i muri i te ako X-ray o te ate, te pūkahukahu, me o te hiko-. kia kawea taua aroturuki i roto i te heke mai, ki te ki te tango i te rongoā tonu te manawanui.

maha, tei te pakeke o ngā kino i runga i te horopeta, e whakamahi ana te manawanui. Me ngana ki te whakamahi i te raau rite pinepine rite taea, me te i roto i rahinga iti. E mea pinepine ai kōhikohiko mokowhiti whakakorenga "Amiodarone" tarukino.

Tohutohu mō te whakamahi - arotake mea e, i roto i te noa'tu o te pānga taha, kua ora tenei tarukino neke atu i te kotahi te ora - e ai ta e tonu te mahi pharmacological o te tarukino te hoki tetahi e rua wiki i muri i tona whakakorenga.

Kei roto Papa iodine, e whai wāhi ana ki te taumata haaputuputuraa o radioiodine i roto i te repe thyroid. Na reira, i te timatanga o te maimoatanga haumanu, i roto i, me te i te mutunga e hiahia ana koe ki te tonu kia whakamatauria hoki te nui o hormones thyroid.

I roto i te mea e tika ana wawaotanga haumanu ki te karo roa ra te rongo, e kore te mea e tika ana ki te tango i te ra tuwhera. kia te tarukino kia whakahaerea ki te tūpato ki te iwi paari ki rehunga whānui ranei i roto i te akoranga o te maimoatanga hāora. Ki te tūpato kia whakamahi i te reira i te atekōkiri o waka me tangata e pā ana ki te kukū ngā nei tikanga.

I roto i te wā o te tuwhena rawa kia wheako ähua o ngā pānga taha, me te hypotension, arrhythmia. Kia puta bradycardia kore ranei o te AV kawenga. He maha atu kia arahi ki ate pōrearea.

I roto i tenei take, tūtohu tatou lavage pekitīlia tonu, rehita waro whakahohe, laxatives saline rongoā tūtohutia. Ki te werohanga bradycardia o atropine, agonists whakamahia o receptors beta-adrenergic, hua kaiwhakahaere.

Te hononga ki ētahi atu rongoā

kia whakamahia Whakatūpatotanga tarukino tukutahi ki ētahi atu taero, rawa ki te he e ratou i te rōpū kotahi o antiarrhythmic. Ehara i te mea e tika ana ki te ngā i te reira ki te fariiraa "erythromycin", "pentamidine" me "vincamine." He he he mōrearea o te tachycardia ventricular Polymorphic i roto i ngā ki "sultopride". E kore e tūtohu ana ki te ngā horomanga CCB me beta-blockers ki "Amphotericin B" me raau taero e meinga he pānga wāhine, diuretic. Ki te tiaki whakamahi i te rongoā i roto i ngā ki corticosteroids, pōuritanga, "Astemizole", "terfenadine." Taea ki te tino whakarei i te pānga o taua raau taero rite "fafati", "Phenytoin" "Tacrolimus" ranei "Digoxin". A, no te whakamahia i roto i te taha ki "cimetidine" pōturi iho te tukanga o te pākia i roto i te tinana.

paerewa Life me te rokiroki

Ko te medicament "Amiodarone", kua whakahaua i runga i whakakorenga o tachycardia, fibrillation ventricular, tachyarrhythmia me te whakaiti kaka Atrial nei mahi, e pā ana ki teuteu kāwai "B" rōpū. Ko iti iho i te tau e toru papa-ora o te tarukino. kia penapena papa i roto i te raumati, pouri me te roto i te taea o ngā tamariki.

Me tino whakahaere te whakamahi o "Amiodarone" tarukino. Ko te tohutaka ki te whakamahi i tuhi i te reira i roto i te tākuta. I roto i tenei take, me tino waho te whaiaro.

medicament Analogs

Ki te koe ohorere kihai i pai ki te tarukino e taea "Amiodarone" analogs e kitea i roto i tetahi rongoā. I roto ia ratou he drugs pērā i: "Amiodarone Belupo" me "Amiodarone Aldaron", "Angoron" me "Atlans" ka whakakapi i te reira ki te rongoā taea "Kordaron" ranei "Kordinil". Rite ki te "Amiodarone" i roto i ona pānga i runga i te tinana tangata "Medakoron" me "Palpitin". I roto i ētahi wā, whakakapia te raau e "Sedakoronom" me "Sandoz".

Enei taero rānei i roto i te taonga kaha taua rite i roto i to ratou pānga antiarrhythmic o rongoā "Amiodarone" ranei. Kei te maha analogues hua noa atu, a he maha ngā wā atu te utu.

mua

mea maha tūroro te stabilization o ratou huru i muri i tango i te rongoa, "Amiodarone". Tohutohu mō te whakamahi - maha e tīpakohia analogs raau e hāngai ana i runga i nga āhuatanga takitahi o te rauropi - fafau ki haerenga i te auau ngakau, pēhanga. A, no te fariiraa taratahi i roto i pota iti, te tikanga kahore raruraru, me nga mahi tarukino tōtika.

I muri i te whakamahi roa o te tarukino i roto i te tahi mau tūroro puta hāhā o te manawa, palpitations ngakau, pau te me te korekore, hīrere tūāhua me te nui haere taiki thyroid, he mate o te wahi gastrointestinal, a i roto i ētahi wā, whakapairuaki, me te ruaki.

whakamahi Tino maha iwi reira i roto i te maimoatanga o te angina, ka mōhio e he reira kahore kino atu ritenga kawemai. e wehi ki te tango i te raau taero ētahi tangata, no te mea te mea i roto ia ratou, he taea ki te meinga i te maha o mate pukupuku ia. Kei te whakapono te reira e kia te tarukino kia tangohia anake i raro i te huru e fakamanamanai ora tangata, i roto i te tahi atu mau tupuraa katoa, kia titiro ai ia mo te rerekē. I tua atu, ka taea e te papa i te pā tōraro i runga i te mahi whakaputa uri tane, i te mea hoki ki te kia whakaaro i to ratou fariiraa.

Otiia mo tokomaha tarukino "Amiodarone" ko reira ei raau rapaau, whakawhetai ki nei kua heke haere te mate, engari te tangata noho ora. Ehara i te meka e pai kia tika rite whai hua analogues. Na reira, i roto i te maimoatanga o te mate ngakau, e kore e tukunoa'i te tarukino atu, ina koa, ki te taunaki i te reira i te tākuta.