"Plagril": tohutohu mō te whakamahi, tākuta tūturu. analogues Drug "Plagril"

Ko Diseases o te pūnaha Cardiovascular i roto i te rongoā hou pea i roto i te wahi tuatahi. Ko te auau te tahuti nei i enei mate he rawa. He raruraru i roto i tenei rohe e taea ta kataka ana i te tangata i te kau o te whanautanga. Heoi, i reira e te hunga i roto i te hopoi mai te whanaketanga ake o te tangata nui "whai". Kotahi mate taua - atherosclerosis. Ki te pā te nuinga pera tenei raruraru ngāwari, me te rapa uaua-momo. Ko te ngako o te mate i roto i taua, e tika ana ki maumaui o te pūmua, me te lipid pākia kohikohi i roto i nga pera o putunga cholesterol me etahi kaipōti o lipoproteins. Ko te kupu i hanga whakatū papa atherosclerotic. Neke atu i te wa, te kiko tūhonohono o taiepa oko i roto i enei whakatū papa whakawhānui, hua i roto i te whāiti o te lumen o te iatuku noa te occlusion.

I roto i te tikanga ki te āwhina i ēnei tūroro, kua whakawhanakehia te kairangahau i te rārangi o te raau taero e taea pōturi iho ranei tino pehi i te tukanga whakawhāititanga (pūhui, hononga) o platelets. E huaina matū ki taua kaha antiplatelet (antithrombotics). Ko tētahi taua tarukino ko "Plagril".

Hanganga me te Composition

E wātea ana i roto i te papa pani ki te māwhero kiriata paninga te tarukino. He tawhio nga papa, biconvex. I tetahi taha Kīkī embossing "C 127". Ko te whakauru matua kaha o te tarukino - clopidogrel. Ratau, i roto i te raau "Plagril" Inn (International Nonproprietary Ingoa) he ōrite ki te ingoa o te wāhanga matua - clopidogrel. Ko te ihirangi rōrahi ia papa - 75 mg. Haunga nga wāhanga matua o te medicament he excipients: microcrystalline cellulose, mannitol, te konutai croscarmellose, te hauhā silicon colloidal, stearate konupora. Manufacturers hua te tarukino i roto i mōkihi namunamu o 10 nga wahi.

Ko te tikanga o te tarukino

Ko te tarukino Ko te inhibitor motuhake (tautāwhi - tautāwhi, pehi tetahi tukanga) te whakawhāititanga (pūhui) platelets. He mahi koronarorasshiryayuschee. Tukanga whakapōturinga mōtepe whakawhāititanga (e pā ana ki 40%) e taea te kite i muri i te 2 haora i muri i ingestion o tarukino i te inenga o 400 mg. I roto i te tikanga ki te whakatutuki i te kakama mōrahi (60% inhibition o te whakawhāititanga) pānga i papa "Plagril", tohutohu mo te whakamahi rite ki te hiahia mo te therapy mō te 4-7 ra. kia te katoa horopeta ia ra i te 50 ki te 100 mg. I roto i tenei take, ka muri pānga antiplatelet mo te huringa katoa ora o platelets (7 ki te 10 ra). I roto i 5 ra i muri i auau tarukino withdrawal o mōtepe whakawhāititanga, me te toto wa hoki ki te mahi tuatahi.

Excreted "Plagril" tākihi me te whēkau (50%, me te 46% te whakaatu i). te kimi i Wā - 120 haora i muri i whakahaere.

Ko te kiritaki matua o "Plagrila"

He rōpū motuhake o te tūroro ngakau e e whakaaturia ana ki te tono i te rongoa "Plagril". E hiahiatia Tohutohu ki te tango i te tarukino mō iwi e mate ana i te atherosclerosis. He whai hua rongoā rite ki te mehua ārai whakaiti i te mōrea o fifi e pā ana ki Thrombosis i roto i te iwi nei i i te infarction myocardial patunga rere pūroto ranei. he pono hoki tūroro mate i te occlusion (te ino o te uruhanga) pera piringa hoki reira.

I roto i te taupiri ki te waikawa ahipirini (ahipirini) kia whakamahia ai "Plagrila" i roto i te tikanga ki te ārai i pōauautanga thrombotic i roto i te hunga e mamae i te syndrome coronary whakapeka. Tenei i taea e ngā iwi ki te angina (puka iu), ki te infarction myocardial kahore hanganga poipoi P. taea e koe te whakamahi i te raau taero i roto i te tūroro e Nōna ka stenting. Ko te ngako o te mahi - tāutanga i roto i te stent oko kua pā (kikokore ngongo whakarewa pai-meshed), i te mea muri rimurapa poihau motuhake, reira te whakanui ake i te uruhanga o te oko, me te whakapai ake rere toto ki te ngakau.

aratau tono: inenga

Ka taea e Medicine "Plagril" tūroro e tangohia-waha, ahakoa o kai. I roto i te tūroro pangia infarction myocardial, patunga rere pūroto whakapumautia tātaritanga ranei e pā ana ki te patency o te ino pera, tangohia te horopeta o 75 mg kotahi te ra. Wā o te maimoatanga therapy i muri Q-poipoi infarction myocardial kia muri ake ki te 35 nga ra. I roto i te patunga rere pūroto, i runga i te pakeke o te huru rānei, kia ngā rongoa i 7 nga ra ki te ono marama.

A, no te whiu i roto i te puka iu, me infarction myocardial waho te hanganga o Q-poipoi ko te nuinga he talena paerewa o papa ko e whai ake: te tuatahi, kotahi-wā uta horopeta o 300 mg, aru e 75 mg ia ra me ahipirini (75 ki te 325 mg ia ra). No te mea e faarahi te rōpū o ahipirini te mōrea o te toto, e kore e nui ake te horopeta kotahi mōrahi 100 mg. maimoatanga Drug - ki runga ki te 1 tau.

Kei te tohua hoki fariiraa "Plagril" antiplatelet therapy mō infarction myocardial whakapeka. Whakahau pire ki te tango i i te horopeta o 75 mg, i roto i te ra kotahi. E tūtohutia ana ki te timata maimoatanga ki te tuatahi uta horopeta i roto i ngā ki te waikawa ahipirini. Pea i roto i thrombolytics tango whakarara (ranei e kore e kia tangohia).

Ki te mea kua whiti tūroro 75 tau o te rohe tau, "Plagril" (rite ki te clopidogrel hoki e manakohia) whakaritea te kahore te utanga whängainga tuatahi. I muri i te ahua o te maimoatanga ngā o ngā tohu kia tīmata rite wawe rite taea. kia muri i te akoranga i te iti rawa 4 wiki.

pānga taha pea o

I roto i te akoranga o te maimoatanga ki te faaineineraa ngā "Plagril" ā-ako e te momo o ngā pānga taha taea i te ngā pūnaha, i nga okana.

maha pūnaha toto upoo- taea te whakautu ki te ahua o te toto gastrointestinal. Iti pinepine kia whakawhanake hemorrhagic patu, te toto i te ihu, me te, i roto i te whānui, i te hua i roto i te wa toto. I roto i te wā onge, kia puta hematomas, hematuria.

Various whakaaturanga i te pūnaha hemopoietic. Ko ētahi o ēnei eosinophilia, neutropenia, thrombocytopenia. Tino iti iho pea ki te whakawhanake i granulocytopenia, anemia ohie aplastic ranei.

I runga i te wahi o te pūnaha io pokapū, me te piringa kia ānini, whanoke, paresthesia, te taninito (mate o toenga, haere tahi e te tikanga o te huringa o ngā huri noa te tinana, hurihia ranei - te tinana o te hurihanga), moemoea, te whakama. Tino onge, engari take o ngā kaupapa aituä puta ki te pūnaha Cardiovascular, i roto i ngā o te pēhanga toto heke, te whanaketanga vasculitis. Bronchospasm me pneumonitis interstitial - pea te tauhohenga o te pūnaha romahā ki te farii i te tarukino tenei.

Nuinga o ngā wā i runga i rongoā "Plagril" (arotake o rata me tūroro whakau tenei meka) tauhohe pūnaha kūnatu. whakakitea te tauhohenga o te tinana i roto i te whanaketanga o te korere, dyspepsia, mamae puku. Iti noa tauhohe taea pērā i whakapairuaki, ruaki, kōroke, gastritis whakapeka me te pekitīlia me tuwhenua duodenal, flatulence. takanga Rare engari taea o mate pērā i colitis, pancreatitis, stomatitis, kakā, reka rereke, te whanaketanga o te kore ate whakapeka.

Ka taea e te pūnaha Osteo-uaua whakaatu ano rumati, myalgia. Ahakoa tupu te reira uaua. kia hua Glomerulonephritis i te tauhohe o te pūnaha mimi. Dermatologists whakaaro e te hopearaa taea o te "Plagrila" he minamina, ponana bullous, ponana erythematous, planus pukoko, katoatia. Pea te whanaketanga o ngā tauhohe mate pāwera i roto i te puka o te angioedema, anaphylaxis, mate serum. O te pānga taha noa kia tuhia kirika, faateiteihia creatinine serum.

Ko te whakamahi o "Plagrila": he aha ki te titiro hoki

Ki te hoki te āhuatanga ngā he mana antiplatelet houhou, kua mahara ki te pokanga ranei, kia whakakore koe te maimoatanga ki "Plagril". Tohutohu mō te whakamahi taunaki ki te rave i te reira i te iti rawa 7 ra i mua ki te pokanga. I muri i te whakakāhoretanga o te tarukino ki te mutu toto ohorere tīmata ka hiahia wā atu. kia whakatupato tūroro e pā ana ki reira, ka tohutohu ki whakamōhio te tākuta e pā ana ki nga toto rerekē. I roto i te moni o te manawanui ki te whakamōhio i te tākuta e pā ana ki te maimoatanga o "Plagrilom" i roto i aua wā, ki te ki kia tetahi pokanga, ranei whakaritea te manawanui kei ki tetahi tarukino hou.

I roto i te akoranga o te therapy rata he nui ki te pupuri i roto i te mana o te tawhā pūnaha o homeostasis (tatau mōtepe, whakamātautau o ngā mahi mahi, APTT). kia aroturuki auau i te mahi mahi o te ate, me ka arotakea rite ine nui i roto i tona mahi i taea e ake i te mōrea o te hemorrhagic diathesis.

Medicaments, Ko nei matua hohe whakauru clopidogrel ( "Plagril" analogs), e kore e tūtohutia hoki te hunga e kua tukua he infarction myocardial whakapeka, i te iti rawa i roto i te torutoru wiki tuatahi i muri i te tīmatanga. e kore e ngaio Medical tūtohu "Plagrilom" therapy, ki te he angina iu te manawanui, ki te patunga rere pūroto i roto i te pokanga karo coronary.

Ki te nui etahi o te tūpato e hiahiatia ki te tango i te tarukino mō te hunga hauā i roto i te mahi o nga whatukuhu.

Ki te haukoti i-fariiraa "Plagrila"?

opani "Plagril" (papa) ako tūroro ki hypersensitivity ātete ranei ki te takitahi wāhanga matua, me te mau pŭpŭ tauturu o te medicament. Kaua e tangohia e te tarukino i tetahi mate predisposing ki toto (pekitīlia me tuwhenua duodenal, hyperfibrinolysis, pūkahukahu mate pukupuku, mate kohi, me ētahi atu). He turanga kaha mo te whakamahi kore-"Plagrila" he kore ate whakapeka, hemorrhagic syndrome. I tua atu ki te runga ake, contraindicated te tango rongoā mō hapu wahine me te u,. E kore e ki te whakahau i te tarukino ki ngā tamariki i raro i te 18 tau o te tau.

teuteu analogues

I roto i te mākete ho'oraa i tenei ra, he rōpū o taero āpiha antiplatelet ( "Plagril" taurite tona ihirangi o te wāhanga matua kaha) e wātea ana makona whānui. Neke atu i te 3 drugs tatini - āpiha antiplatelet i te whakauru taua hohe (clopidogrel) me i te inenga taua (75 mg). I tua atu i ngā kaiwhakanao Russian hua antiplatelet kamupene rongoā Indian, hinonga Hungary, e Iharaira, Malta, France.

"Dr. Reddies Laboratories" "Plagril" hua iho he kamupene Indian. Na roto i te faaauraa, e nehenehe tatou e whakauru i te French "Plavix" German "Clopidogrel Ratiopharm," Hungarian "Clopidogrel-Richter," Iseraela "Clopidogrel Teva," Maltese "Liporel" Makeronia "Listab 75". "Zilt" taea te taratahi i te tino rongonui, me te whānui i roto i te tono āpiha Russian.

"Zilt" - Russian "Plagril"

Ko te taonga kaha matua o te faaineineraa "Zilt" ( "Plagril" i roto i taua he reira tino ōrite) he clopidogrel. no rongoā ki te rōpū o āpiha antiplatelet. Ko te horopeta tuatahi (mō "Zilt" - 400 mg) i muri i te 2 haora i muri i whakahaere pōturi mōtepe whakahiato. Just rite "Plagril", "Zilt", e whakaratohia ana mō te fariiraa i 50-100 mg ia ra ka whakarato i te pānga haumanu mōrahi i muri i 4-7 ra.

Medicament metabolized i roto i te ate. Ko te hanganga o te toto kitea o metabolites kaha te. Tata 50% "Zilta" excreted e nga whatukuhu, te toe 46% i roto i 5 ra i muri i tangohanga ka mawehe atu i roto i te whēkau.

Tuhinga hoki te whakamahi o te "Zilta" ko te taua rite i roto i "Plagrila": te ārai o te thrombus hanganga i roto i te tūroro pangia infarction myocardial, patunga rere pūroto ranei te mamae i disorders uaua patency.

whakaaro kiritaki

Ka rite ki tetahi raau, te "Plagrila" He rua aromatawai pai o kiritaki, e rua arotake pai, me te kino. He tūroro i roto i nei kua te tarukino kua whakaritea mo te maimoatanga o te angina , ka whakakitea ia he tarukino rawa whai hua. Ki te ona whakamahi o te whakaeke tangohia e wahi ranei i te katoa, ranei ka tino iti ratou. Fakataha ki kiritaki i roto i te aro mātai o ngā rongoā "Plagril" whakautu i rata.

Heoi, ka taea e koe te whakatau me ngā kitenga e pā ana ki te pānga taha meinga e te whakamahi o te rongoā. tuhituhi ētahi iwi e pā ana ki te ahua o karawarawa, mārama whakakitea etahi anemia. Ko ratou tūroro me wāhanga o pāhoahoa nui, a te tino rerekē tohutohu disorders i roto i te pūnaha kūnatu. Rare, engari e taea te rongo i runga i te matatau i roto i te tukanga o te fariiraa "Plagrila" whewhe pekitīlia whewhe duodenal ranei.

I roto i te whānui, kia mea ai e tūnga te tarukino "Plagril 'tohutohu mō te whakamahi te rite te nui tarukino nui e kore he hototahi ki ngā rongoā katoa. Kua he rārangi tika whānui o contraindications, ka taea e meinga he rota o ngā pānga taha i te whānuitanga o ngā pūnaha, i nga okana. Ka taea e te whakamahi whakakeke whakaongaonga nui tōraro (me ētahi wā tina heke) hopearaa mo te hauora o te manawanui.

Ko te mutunga i te runga ake katoa he whaiaro-kitea. kia "Plagril" mo te akoranga maimoatanga kia whakaritea e te rata haere. Na te kōwhiringa pai o te maimoatanga ki tenei tarukino - i roto i te hōhipera, me te i raro i te mātakitaki o ārahi tohunga. Anake i roto i tenei take e taea tatou tumanako mo te pānga pai o te tarukino me te mōrea iti o ngā pānga taha.