"Atsekardol": tohu hoki te whakamahi, tohutohu, arotake, analogs

I roto i nga tikanga o te antiplatelet therapy, e kua whakamahia mo te ārai o ngā Cardiovascular whakapeka, kua roa kua he waikawa ahipirini take matua (ASA). Synthesized i roto i te 1887, he reira nui atu i 125 tau kua kua kaha whakamahia i roto i te mahi hauora hei kaihoko antiplatelet me antipyretic. A, kia rite ki ngā te taonga tarukino kaha i roto i te "Atsekardol" faaineineraa, tohu o nei āta whakawhānui rite te ako huarahi pathogenic o mate.

medicament āhuatanga Pūnaha

Ko te taonga faaineineraa kaha rite ki te whakarōpū pā ana ki te tikanga mō te ārai whakahiato. I roto i tenei raupapa o Ack ko te hanganga matū tino pai e taea o rawa e taea ki te whakarato mōtepe whakawhāititanga poka katoa. Tata tarukino "Atsekardol", tohu hoki te whakamahi, me ona analogs puka inenga i roto i ngā o pharmacodynamics, whakakitea te whai ake:

• tona whakauru hohe - ASA mediating pānga antithrombotic i runga i te atherosclerosis o pera papamuri;

• optimally dosed tarukino mo te ārai o te mate Cardiovascular;

• tona puka inenga whakaiti te ASA pānga gastrotoxicity;

• Ko te utu tino i roto i te whakataetae hua ki te kakama ōrite takanga.

Ko te pānga o te ārai Thrombosis ASA faataa pā hanganga o prostanoids. No te mea inhibition o Cox-1 - whakaohooho kōkiri take thrombus hanganga - - mōtepe Cyclooxygenase-1 te whakawhāititanga o platelets toto. puta inhibition hanganga o thromboxane A2, tīmata te tukanga o te tāpiritanga o platelets ki te wahi pakaru o te taiepa oko.

Pūtake me te kiripuaki gastrotoxicity

tohu Target mō "Atsekardola" ngā ārai o thrombus hanganga. Heoi, ko te ASA, te whakauru mātātoa o te tarukino, i reira he he pānga houhou e pā ana ki cyclooxygenase nonselective. ohorere hoki faati'a faahou o pūtau epithelial o te wahi pekitīlia. Te riroraa i raro i te mana o pukuriri taiao puku waikawa, e atu ratou pakaru, e ai te whanaketanga o te gastral mumura ma'i. He wā (e pā ana ki 3.5% o te wā katoa) whakaoho reira toto i roto i te wahi kūnatu.

Hoki waihanga, e whakamahi "Atsekardol" tohu mo te whakamahi atu whānui hoki o te haumarutanga nui. memeha te reira a te whenumi anake i roto i te-duodenum 12, e tohu ana ASA kardioformu enteric. Tona whakapā ki te pūtau o te kopu ko tata whakakorea, reira leva tona gastrotoxicity pānga taha. Kei te whakaiti pānga ino Local "Atsekardola", no te mea ko te tarukino i te puka o te enteric kua whakaaro rite te inhibitor whiriwhiri o Cox-1. Ahakoa e hoki Cox-2 inhibition wahi i roto i te whēkau, e kore e nei whakaaturia waimaerotanga nui.

He pānga nui o te puka inenga "Atsekardola" Ko te gastrotoxicity whakaiti rohe tika. Nā ki te aroaro o te patu waikawa i roto i te puka o te konupora waihā tūponotanga kino pekitīlia heke noa teitei. A i te kau i runga i te mākete pharmacological o te Russian Federation "Atsekardol" Ko reira tetahi o toru moni ki enei āhuatanga. Toe i te utu tino i roto i rite, kei te tano e tano te reira no te whakamahi pūmau.

Place "Atsekardola" i roto i te therapy antithrombotic

Kei te tono hāngai ASA mo te prophylaxis o tītohu thrombotic i runga i te plurality o rangahau haumanu. Kua whakapumautia ratou ona whai huatanga i roto i te whakaiti te tahuti nei manawanui i te mate Cardiovascular. I roto i te ngā:

• ASK 16% te tahuti iti i roto i tūroro i rōpū mōrearea Cardiovascular tiketike:

• 25% whakaiti i roto i te pā o te patunga rere pūroto;

• 25% te whakaiti i te mōrea o te thromboembolism, iatuku pūkahukahu me ona manga;

• 29% te whakaiti i te tūponotanga o symptomatic Thrombosis venous o papatoiake iti ranei pito;

• 33% whakaiti i roto i te pā o te infarction myocardial.

Ēnei pānga, me te whakarato tarukino tonu "Atsekardol" tohu mo e iti whānui atu zheludochnorastvorimoy ASA. Na inaianei aromatawaitia te mana o te mahi antithrombotic o taero antiplatelet hou te anake i roto i te whakarite ki a ia. Fakatatau ki, "Atsekardol" rite te haumaru ake, kia noho te wahi pokapū i roto i te maimoatanga prophylactic o tūroro rite ki te whakaaturanga.

tūroro ope ki tohu mō te whakamahi

I roto i te faaineineraa "Atsekardol" tohu mo te whakamahi, utu, whai huatanga me te mōrea o te whakamahi i optimally taurite. taea tenei ki a koutou te tango ASA i te puka inenga o te whānui o te tūroro ki te āhuatanga mōrearea occlusive. Na te whakakorenga o te nuinga o nga pānga taha o nga take tarukino i roto i te wā e whai ake nei:

• (ACS) whakapeka syndromes coronary ki tairanga, whārua tonu wā ST i runga i te ECG ranei;

• whakapeka disorders kaka (kaka) tohanga (ADCC);

• rangitahi (roro) whakaeke rere pūroto (Tia);

• heke i raro i enei mate ki te ārai i ngā take recurrent;

• ki pectoris angina kainga te ārai o ACS;

• ki paroxysm ranei ahua tūturu o te fibrillation Atrial;

• uaua tīponapona venous.

substantiation Pathogenetic o tono "Atsekardola"

Enei tohu mō "Atsekardola" e tika ana ki te pānga haumanu o te tarukino. Kei te tōtika te whakamahia te reira i rite te tikanga o te ārai matua Thrombosis i te wāhi o te rohe, me te concentric whakatū papa atherosclerotic. I roto i ēnei wāhi e tika ana ki te whāiti o te rere toto matua fakahohaasi te ki te hanga i te rere vortex toto. pēhanga Mechanical i runga i nga wahi whakaiti o te endothelium arata'i ki tona haehae. E whakaae ana pūnaha toto coagulation tenei whenua kia rite ki te takahi o te tapatahi iaia, e titau platelets kati aunoa ki te hanga i te katinga.

Ko te tāpiritanga o platelets ko, te wāhanga tuatahi o te thrombus hanganga, i runga i te otinga o e kia hanga i te anga mo te heke mai o te katinga toto. Na, faarahi tona rahi e tika ana ki te roa o ngā pūtau toto. tukanga otinga tonu ahu hemostasis ki kino (neke atu i te 75 rohe%) whāiti o te lumen oko. E mea pinepine noa i te reira e hipokina te rere toto i roto i te iatuku, ko nga wāhi e i whangai i mua i runga i tona wheako ischemia. Tenei tukanga Ko te pūtake o ACS me patu, na ko te tino nui i roto i te tikanga ki te whakaiti i te tahuti nei takitahi i atherosclerotic ngakau me te brachiocephalic pera ārai o enei ari.

Pharmacodynamics mahi antithrombotic "Atsekardola"

Āpitihia ki te tarukino "Atsekardol" ā ako (whakaahuatanga o te hua) e kore e whakaata ona pānga pharmacodynamic, a whakaahua ana te reira i roto i ngā o ngā āhuatanga pānui, me te fariiraa. Heoi, e kore e whakaahua reira he pānga motuhake o ASA, reira hau i te manawanui o te mōhiohio nui e pā ana ki te huarahi o te mahi. Ko ona hātepe raupapa e whai ake:

• inhibition o Cox-1 me te mutunga o te ariā o prostanoids;

• hua Tuhinga tina heke o te mōtepe thromboxane A2;

• fakafaingata'a'ia'anga mōtepe tāpiritanga ki te hē o te endothelium;

• inhibition o tukanga adhesion mōtepe;

• te eita o hanga he thrombus occluding te lumen matua.

"Atsekardol" i roto i ngā āhuatanga whakapeka

piri hoki ki te tarukino "Atsekardol" tohutohu mō te whakamahi (whakaahuatanga whakarāpopototanga) e kore e whakarato mōhiohio ki te manawanui e pā ana ki te taea o tona whakamahi i te wa o te whakawhanake disorders tāhapa o te tohanga toto i roto i te ngakau roro ranei. I roto i ngā, me te whanaketanga o te āhuatanga syndrome haumanu o infarction myocardial haaparuparu ranei, a kia tono ai ASA.

Me papa ki tararua ana te tarukino (i te horopeta o 150-300 mg), me te kore ki te horomia. Ki te te tarukino i roto i te horopeta o 50 mg, te kau o te huru whakapeka titau te manawanui papa ngau 3-6 e rua ka te inenga o te 100 mg, te papa 2-3 ka 300 mg, te papa 1. Ko te taputapu ohotata, i nei tino iti tūponotanga o nui Thrombosis iaia.

Contraindications ki te whakamahi o "Atsekardola"

I roto i te faaineineraa "Atsekardol" (papa) tohutohu mō te whakamahi, ngaio tūturu me raraunga rangahau ho'oraa whakaū te toenga o ngā mōrea me ngā painga o te tono. Heoi, contraindications tika ki comorbidities tā whakaaro ka tango i te tarukino, me te kōrero i te tohunga. E wehea Contraindications ki tonu (tino), me te wā. Pūmau he:

• ātete tarukino ki ASA, bronchoconstriction;

• kanokanototo intracranial wāhi rerekē;

• hemorrhagic vasculitis ;

• Kei te riria te reira ki te whakamahi i roto i taiohi me tamariki e tika ana ki te mōrea o te syndrome o Reye ;

• Kei te riria te reira ki te farii i te wahine i roto i te hohipera, i roto i ahau, me III huatū o te hapūtanga.

Hoki ahua iti wā fariiraa me contraindications whanaunga:

• hepatocellular me täkihi;

• te aroaro o te toto haere tonu, wawe wā postoperative (contraindication rangitahi);

• takawhita i te wa o te raruraru, takawhita whakakeke;

• whewhe 12 whewhe duodenal ranei exacerbation pekitīlia (rohe wā).

pānga Maha "Atsekardola"

I tua atu ki ngā pānga paerewa, me te pai ako meinga e inhibition o Cox i te vai Ack me tetahi atu mahi. I whakakitea te reira i roto i te raupapa o rangahau tauanga i roto i te mate pukupuku, me ngā pokapū geriatric i roto i te US. I roto i te akoranga o ratou mohiotia te pānga pai o ASA mo te ārai o mate mārere - mate pukupuku colorectal rerekē localizations.

Na whakamatau tatou te huarahi motuhake o te mahi tiaki o te tarukino. E ai ki te nuinga o ngā kairangahau me matahauroa whakaae i runga i te predominance o te pānga inhibitory o Cox-2 i roto i te piro o raro. Hëoi te ariā o te prostaglandin E2, Ack taea āwenewene whakahaere i te whakangaromanga me tārua o ngā pūtau. E te ara, ko e uho ia te whanaketanga o te puku i tenei tukanga ngā pūtau.

Faahopearaa i runga i te pūtake o meka kï he rite whai: rongoā "Atsekardol" ako, tono, ngaio tūturu e whakau tona pānga whārite, ano e taea te whakamahi rite he prophylactic mo te ārai o ngā tukanga puku i roto i te wahi o raro o te wahi gastrointestinal. I roto 5-12 heke tau manako te mōrea o te mate pukupuku te mate, e fakanatula faarahi te roa. Otiia e kore e taea te whakamahi Ack mo te maimoatanga o te adenoma colorectal kua whakawhanakehia mate pukupuku whēkau ranei.

Analogs faaineineraa me kē

āhuatanga Hua "Atsekardol": tono, kaiwhakamahi, analogs, tohu hoki maimoatanga antithrombotic koutou e taea e te whakamahi i te reira ki te hamani i te whānui o tūroro ngā. Heoi, i roto i te raupapa o āpiha antiplatelet, e kore ko ia anake nga tikanga. I roto i Russia reira e pā ana ki te 20 Ack kano, wahi o nei hua e i roto i te puka zheludochnorastvorimoy. tuku ratou i te tūāwhiorangi haumarutanga "Atsekardolu".

momo Enteric o ASA ( "Cardiomagnyl", "Polokard") whakaaturia i runga i te mākete pharmacological, utu tino teitei. Hoki te faaineineraa "Atsekardol" utu marama maimoatanga he 25 moni. Mutu ōrite ki ritenga i roto i te taua whānui o te haumaru e rua-hautoru atu. taero Foreign di- rawatia e rima nga wa ki runga ake i te utu o te maimoatanga o te pūtea mō kore painga kitea ki te manawanui te fariiraa i te "Atsekardol" ranei. He ōrite hoki ngā tohutohu mō te whakamahi, maimoatanga, arotake, tauākī i analogs o tenei tarukino.

Whakatau e pā ana ki te painga me ngā mōrea o analogues "Atsekardola"

Noho te tino utu, te tarukino "Atsekardol" tino e ü ana ki te whakaritenga o matahauroa. Ko taurite ki te whakamahi o tono mahi pērā i āpiha antiplatelet te mōrea o tona whakamahi. Reira tōtika ārai Thrombosis recurrent o te ngakau me te toto oko o te roro, e whakamahia i roto i te fibrillation Atrial, Kei te whakamahia hoki uaua tīponapona. Na whakaritea ki nga analogs painga rohe "Atsekardola" he utu.

Tenei meka tino whakanuia ana te hāngaitanga o te "Atsekardol" hua: ko te utu o te tarukino, ko te neke atu i te 20 moni. Ko tino iti iho i te utu o ētahi atu āpiha antiplatelet tenei. Ano, i roto i te raau taero hua ASA i te puka enteric haumaru tino, ara rite iti taurite "Atsekardol". Noatia, e meinga ana te reira e te maimoatanga o te mate whakahuatia i runga ake, me ratou ārai. ka whakanui i āta te maha o ngā wāhi tono.