"Methotrexate" i roto i te kaikōiwi: arotake. Tohutohu mō te whakamahi, he whakaahuatanga o te faaineineraa

kaikōiwi, ki te iritihia mo'oni reira ki Kariki, e pā ana ki te āhua o te mumura. Ko te pātai o te mea take whakapataritari i te whanaketanga o tenei mate e kore tonu e haamaramaramahia. mōhiohio tītaha e faarahi te maha o leukocytes i te toto, ka nui haere ngeniwhero auau parataiao (ESR), hanga taea reira ki faaoti e te tukanga o te whakawhanake i te mate, ko te āhua ma'i pee. Kei te whakapono te reira e te hiringa mo te whanaketanga o te mate ko te mate, whakapataritari raruraru i roto i te mahi o te pūnaha ārai mate. Heoi, i raro ki tenei, e kore katoa engari anake te hunga e whai i te aamu utuafare. Ko te hua o te whakauru i te mate ki te tinana tangata, ko te hanganga o complexes ārai (i wheori, paturopi, a na i runga i. P.), nei kohikohi i roto i nga kopa, me te arahi ki te kino tahi.

I roto i te nuinga o te wā, maimoatanga o tenei mate nanakia he mamae tamarыraa i, tērā te rere o te tukanga mate, me te whakaora i kino (rite he taea i roto i ia take) te whakamahi i ngā tikanga hāparapara.

Drugs mo te maimoatanga vai tēnei wā nui i roto i. Ko tētahi o enei ko te "Methotrexate". I roto i te kaikōiwi (arotake o kaimahi hauora me tūroro whakau tenei mōhiohio) mea he whai hua medicament nui, ka kia ua te hua o tona pānga mō te wa roa.

Composition me te mahi

Ko te whakauru matua kaha o te tarukino he methotrexate. Tenei nitostatik, he enemi o te waikawa folic. I tēnei wā, mō te tērā te ahunga whakamua o te kaikōiwi tukanga maimoatanga "methotrexate" whakamahia te atu pinepine atu i te tahi atu tikanga. I roto i te ngako Ko te tarukino antitumor, he māngai cytostatic, tenei inhibits whāū (wehenga pūtau autaki) inhibits te tupu o kaha proliferating te kopa, inhibits te whanaketanga o te pukupuku.

E ai ki ngā tatauranga, kitea te tōtika o te tarukino i roto i 80% o tūroro, he kite i muri i 2-6 wiki i muri i tīmata therapy te au pai. I muri o te maimoatanga he wā roa (ki runga, ki te 5 tau) therapy "Metotraksatom" whakakore nui iti iho i tetahi atu rongoa whakamahia ki pōturi te whanaketanga o te kaikōiwi.

puka Tuku o te tarukino

Whaiaro rongoā ko te ōrite Russian o te Austria "Methotrexate Ebewe". Ko te kaihanga tarukino taketake tuku ona kiritaki i roto i te maha momo rerekē o te hanga. E arumoni wātea ana i roto i te toru toketaá o 2.5 mg, 5 mg me te 10 mg o te wāhanga kaha matua papa. Kua Kikī katoa o ratou i roto i oko polypropylene o 50 nga wahi ia. I tua atu, "Methotrexate" (Austria - kaiwhakanao) e taea te hokona i te horopeta o 50 mg / 5 ml i roto i te otinga mō te werohia. Ampoules hanga o te karaihe pouri me te Kikī i roto i te pouaka pepa.

Ko reira taea hoki ki te hoko i te medicament i te puka o te kareti mo te faaineineraa o infusions (droppers). Inenga - 100 mg / 1 ml. I roto i taua puka, "Methotrexate" e hokona i roto i te oko o 5, 10, 50 ml. I roto i te pouaka pepa Kikī kotahi oko.

Tuhinga mō te fariiraa i "methotrexate"

Tuhinga hoki te whakamahi o te tarukino ko tino motuhake, mai i tona whakaaro matua - te whawhai ki te pukupuku. E tūtohutia ana ki te tango i "Methotrexate" i roto i te wā i reira te te mamae i te manawanui i whakapeka kanisā lymphoblastic me lymphomas nehodzhinskimi. Ano, kua whakaritea a reira mo mushroom pukupuku trophoblast mycosis me te psoriasis (i roto i ngā wāhanga nui).

Ano, ki te kahore te tahi atu whakaora me taero e whai he pānga appreciable tono "MTX" mo kaikōiwi. Reviews rheumatologists tohunga i runga i ngā rongoā kaua pai.

Tuhinga mo te fariiraa o "Methotrexate Ebewe" ahua nui. Mataotao whakahau reira ka malignancies te manawanui ngā pūnaha me whēkau: pukapuka mate pukupuku me te mate pukupuku uma, osteosarcoma me sarcomas kiko ngohengohe, testicular me pukupuku ovarian, Kaposi Jung, retinoblastoma me mate autoimmune.

Ko wai e kore e tangohia e te rongoā?

Ko te tautokohia ki te tango i te tarukino ki te iwi ki te hypersensitivity ki te whakauru matua kaha. Contraindicated fariiraa "methotrexate" hapu wahine me whaea te u. Ehara i kaitūtohu ki ine tīariari o te ate, me whatukuhu, hematological huru disorders (anemia, thrombocytopenia, leukopenia). E kore e taea ki te tīmata i te rongoā maimoatanga ki tūroro i roto i te wāhanga whakapeka o tetahi mate hopuhopu, hē ārai tūroro syndrome. Ka rite ki te ōrite Russian, me te taketake "Methotrexate" (Austria) kore e whakaaetia ki te hoatu i to ratou tamariki ki runga ki tau e toru.

A, no te homai he maha o mate tarukino i te tūpato nui. Ēnei raruraru ngā mariao puku , me te 12 whewhe duodenal, colitis ulcerative, me maroketanga. I roto i viral, Me hoki fungal me mate kitakita ki te mahi rawa äta. Ki tenei rōpū no take i mua i iraruke te hahau ranei.

pānga taha pea

"Methotrexate" i roto i ampoules, papa, ka taea meinga infusions he maha o ngā pānga taha. Tino taea ngā raruraru nui whakatika i te pūnaha hematopoietic (leukopenia, thrombocytopenia, a na i runga i. P.) A gastrointestinal (dyspepsia, anorexia, ate tāoke, pancreatitis). Ka taea e te pūnaha io urupare ki pāhoahoa, te momoe, paresis, haurangi. pota High o te raau taero e taea tīmata te whanaketanga o te encephalopathy. Ine i te whekau ataata me te pūnaha Cardiovascular (hypotension, effusion pericardial, thromboembolism).

Kia whakawhanake kore romahā, ma'i mate pūkahukahu taunutia, hāhā o te manawa, maroke, mare nonproductive, kirika. Ki te pūnaha genitourinary, i reira ko te mōrea o te mate tākihi nui hēnga o ōna whatukuhu ranei. rangirua pea o spermatogenesis me oogenesis, heke libido, pākoko, paruparu.

Ki te te wahine he hapu, "Methotrexate" (werohanga, papa, maturuturu) e taea meinga materoto, malformations ranei te mate fetal.

papa dosing talena

I roto i te maimoatanga o neoplasms mārere hangaia takitahi talena o pire, me te tei reira ki runga i te wā iahiko kimó. A, no te haere mai te reira ki te tono o te medicament "MTX" mō te kaikōiwi (whakautu manawanui i pūāhua pai), ko te nuinga te horopeta tuatahi 7.5 kotahi mg te wiki. Ka taea e koe te tango i te horopeta katoa i kotahi, a ka taea e wehe e koe i te reira ki te 3 pota i 12 wā haora.

I roto i ētahi wā (ki te whakatutuki i tētahi pānga tino pai) kia nui haere ai whängainga wiki. Heoi, e kore e nui te reira 20 mg. A, no te tutuki te pānga haumanu hiahiatia te, te inenga kia kia āta heke ki te iti. e kore te hauora pāngia te roanga ikeiketanga o te akoranga maimoatanga.

Werohanga o "methotrexate"

A me pehea te mahi i te werohanga ki te tarukino "Methotrexate"? Werohanga mō te kaikōiwi tīmata ki te hanga i te inenga o te 7.5 mg ia wiki. Ka taea te mahi i tēnei subcutaneously, intramuscularly pâmuhia ranei. Ki te i pai noatia te raau taero i te manawanui, e taea te āta nui haere te horopeta wiki i 2.5 mg engari e kore e neke atu i te 25 mg. A, no te tae i te pānga haumanu te (te nuinga o 1-2 marama i muri i tomokanga o maimoatanga), te horopeta kia kia āta heke ki te iti tika. Hoki ia manawanui ki kaikōiwi, inenga kia āta whakaritea mō te pānga ikeiketanga o te maimoatanga. Kua whakaaturia ngā haumanu e "Methotrexate" pai ake whenumi me homai urupare taha iti, ki te te subcutaneously werohia intramuscularly ranei.

Ki te fariiraa tonu o "methotrexate" tonu tuatahi pānga haumanu pai mō te rua tau. Ki te whakakore koe tarukino kaikōiwi he pānga i roto i te 3-6 wiki.

pota nui

e kore te nui pota medicament Russian tarukino "Methotrexate Ebewe" (papa, werohanga, infusions) ranei whakaaturia tetahi tohumate motuhake. Ka taea e tuwhena rawa meka e kukū methotrexate taumata i roto i te wē toto.

he tonu (optimally i te haora tuatahi) o tono raau, i te mea te folinate konupūmā Treatment. Me kia te rōrahi o te injectate rite ki nui atu riro te horopeta "methotrexate" ranei. kia whakaritea pota atu o te konupūmā folinate i te tākuta rite hiahiatia. I mua i tomo koutou ia horopeta muri, a ka nga 6 haora puta noa te tukanga ki te whakakore i nga tohu o te tuwhena rawa o te whakamahi i raau he tika ki te whakatau i te pH o te mimi. ka whakaiti taua mehua te tūponotanga o te whakawhanake nephropathy.

i roto i te mōkihi o mehua e hiahiatia ana ki te whakakore i te pānga o te tuwhena rawa o rongoā hoki ngā hydration me mimi alkalinization. ka tere ēnei ngā tukanga ake te excretion o methotrexate.

Ngā pāhekoheko ki ētahi atu matū, me taka

Ki te he kauti he manawanui, a kia te papaki te whakarite o "Methotrexate" rongoa "Methotrexate Ebewe" taero arthrifuge horopeta ranei. whakamahi katoatia o salicylates, phenylbutazone, fenitoiona, sulfonamides, he maha o etahi paturopi (tetracycline, rongoā paturopi, chloramphenicol), anticoagulants pānga autaki me ngā rongoā hypolipidemic taea arahi ki te tāoke kino, ara te mate.

nui o "methotrexate" i roto i te whakarara ki NSAIDs taea meinga te mate i hematologic kino, me te tāoke gastrointestinal. Ko te huinga o NSAIDs me iti-horopeta rongoā i mua i tatou kia whakaiti i te excretion o te muri i te tubules tākihi.

taero Hepatotoxic (e hāngai ana i runga i sulfasalazine, azathioprine, te waihā) ki te whakapiki ake i te mōrearea o hepatotoxicity, gematotoksicheskim - gematotoksichnosti "methotrexate". tono katoatia o te tarukino me te radiation therapy maimoatanga taea meinga wheua wheua whārua.

tohutohu motuhake

I mua i te tīmata koe maimoatanga rongoā "Methotrexate" (werohia, ki te pire e hāngai ana - e kore e mea faufaa), he mea e tika ana ki te whakahaere i te tatau toto oti (ki te mohio te taumata o platelets), mataora (ki te whakatau i te uara o whākōkī ate, albumin, bilirubin), mahi pouaka X-ray. I tua atu, he mea e tika ana ki te titiro i te whatukuhu, i roto i ētahi wā, e kore e whakamātautau hira mō te kakā me te mate kohi.

I roto i te tikanga e kore e ki te mahue i te kau o te haurangi, he mea e tika ana ki te whakahaere i te hanganga o te toto piringa (maha o leukocytes me platelets), mahi tākihi, mahi transaminase ate, taumata o mua i roto i te serum. I mua i ia whakamahi o "methotrexate" mucosa-waha, me te pharynx kia tirohia mo te aroaro o keha. kia takina te tukanga o te wheua wheua hematopoiesis i te timatanga o te therapy, kotahi i roto i te maimoatanga, me te i muri i tona katinga.

awhe utu

te tuku puka (papa, i werohia) me te horopeta - te āhuatanga matua e pa ana i te utu o "Methotrexate" tarukino.

Price tākai o papa (50 RW.) Ki te he horopeta 2.5 mg kia ngā i 240 ki te 250 moni. Ko te nui ano o papa horopeta 5 mg taea te hokona mo te nui o 390 ki te 420 moni. Packaging te tarukino ki te horopeta teitei (10 mg) ka utu 530-550 moni.

Ko nui atu te utu i te otinga mo te werohia, ka ko nui whānui te horapa utu. Hei tauira, medicament 5 ampoules ki te inenga o te 50 mg / 5 ml i roto i te tahi mau pharmacies taea te utu e pā ana ki 1200-1300 moni, i ētahi atu - 4900 moni.

whakaaro kiritaki

He rua ngā whakaaro pai, me te kino o te tūroro e pā ana ki ngā rongoā "Methotrexate". I roto i te kaikōiwi, te nuinga tuhia nga arotake i te au pai (e pā ana ki 80% o tūroro ite miramira i roto i te marama tuatahi 1-1.5 o maimoatanga). Heoi, ka taea e tetahi pinepine rongo e pā ana ki te pānga kino o te tarukino i runga i te manawanui, te whanaketanga o ngā pānga taha o rerekē te pakeke i runga i te wahi o ngā pūnaha, i nga okana.

Hei whakaiti i te pānga kino, "Methotrexate" kia whakaritea anake i te rata haere, a hoki ia kua ki te whakawhanake i tētahi mahere maimoatanga, me te whiriwhiri i te horopeta whai hua.