Raau taero Antileukotriene o te whakatupuranga hou: he rārangi o te pai

taero Antileukotriene tohu te piha haapiiraa hou o āpiha e whakaiti nga tukanga inflammatory e he etiology mate pāwera hopuhopu ranei.

I roto i te tikanga ki te mahino te parau tumu o te mahi o enei taero, he mea e tika ana ki te matau ki ta e nga leukotrienes.

leukotrienes

He kaiwhakaako o mumura ratou. E ai ki to ratou hanganga matū, he ratou waikawa ngako, e kua hanga e o te waikawa arachidonic.

E whai wāhi Leukotrienes i te whanaketanga o te huangō. I tua atu i histamine, he kaiwhakaako o tauhohe mate pāwera o te momo tonu ratou. Ka taea e Histamine meinga he bronchospasm wā-poto tere engari me meinga leukotrienes spasm roa me te roa.

Ka rite ki taero antileukotriene whakarōpūtia?

I tēnei wā, Whakaröpütia leukotrienes e whai ake: A _4, B _4, C _4, D _4, E _4.

Synthesis o leukotrienes i takea mai i te waikawa arachidonic. Ko reira i raro i te mana o puta 5-lipoxygenase ki leukotriene A _4. I muri i taua i reira ko te tauhohenga Niniiraa, i hua i roto i te whai ake puka leukotrienes B ₄ -C ₄ -D ₄ -e _4. Ko te hua whakamutunga o tēnei tauhohenga - LTE _4.

Whakapumautia e LTE _4, D _4, E ₄ taea meinga pānga bronchoconstrictor, hua o te hūpē secretion kia whai wāhi ki te whanaketanga o te edema, tautāwhi i whakawātea mucociliary.

B _4, D _4, E ₄ E mahi chemotactic, i.e. kia kukume neutrophils me eosinophils i roto i te rohe tukanga inflammatory.

Kua whakaaturia Scientists e kua whakaputaina leukotrienes e macrophages, pūtau rewa, eosinophils, neutrophils, T-lymphocytes, e āta whai wāhi ana i roto i te tauhohe inflammatory. raau taero Antileukotriene i roto i te huangō te maha whakamahia.

I muri mai i te pūtau ki whakapā ki te allergen me tautauā puta Airways ranei i muri kohakoha tinana, whakahohe LT te kōtuitanga. Ko te, tīmata te ariā, ka te osmolarity o piki ihirangi arahau.

Wha ngā rōpū o taero

Kei te mohiotia te reira i teie nei i roto i te raau taero katoa wha ngā rōpū antileukotriene:

1. "Zileuton", i te mea he inhibitor tika o 5-lipoxygenase.
2. Formulations e he inhibitors pīngore, whakatupato tukanga o here te pūmua ki te waikawa arachidonic.
3. "Zafirlukast", "Pobilukast", "Montelukast", "pranlukast", "verlukast" e he kau fa'ufa'ufono ko o receptors leukotriene sulfidopeptidnyh.
4. Drugs e he kau fa'ufa'ufono ko o leukotriene B ₄ receptor.

Ko te tino ako he taero antileukotriene o te rōpū tuatahi me te toru o nga rōpū o moni. A feruri i teie rōpū i roto i te taipitopito atu.

"Zileuton"

"Zileuton" Ko te inhibitor reversible o 5-lipoxygenase. He mea e taea ki te tautāwhi i te hanganga sulfidopeptidnyh te LT ko RT _4. kia whai i te tarukino pānga bronchodilator tonu ake ki te rima haora. Hoki ko reira e taea ki te ārai i te takanga o te spasm arahau, i te mea he putanga o te rongo ki te rangi makariri "ahipirini" ranei.

rangahau maha whakamatau e "Zileuton" whakaritea ki tūroro mate i huangō arahau mō te kotahi ki te ono marama, ka taea e whakaiti i te hiahia mō te manawanui ki te hau β2-agonists me corticosteroids. He horopeta "zileuton" kotahi faaara te takanga o te tihe me te hāhā o te nasal manawa i roto i tūroro e mamae i te Rhinitis mate pāwera i muri i whakahaere nasal o whakapāwera.

Ko te therapy ono-wiki ki "zileuton" huangō atopic whakakitea he hua nui. mea Doctors-kounga teitei e tukupu ana o eosinophils me neutrophils. Ano, heke reira take puku necrosis i roto i fluids lavage bronchoalveolar i muri i te momo allergen whakamātautau. Ko te mea ko taero antileukotriene ahurei, e hāngai ana te huarahi o te mahi kei te i runga i tenei.

"Zileuton" e āhuatanga e te wa poto ngā, i roto i nei i reira ko tona hawhe-ora. kōrero ana tēnei e kia te tarukino kia tangohia pinepine nui ki te wha nga wa he ra. I tua atu, "Zileuton" ahei o te whakaiti i te paranga o theophylline. Me whakaaro te reira, ki te te riro te reira theophylline tangohanga whakarara, me te "zileuton". Ko, kia heke te horopeta tuatahi. Ki te whakaritea "Zileuton" ko te wā roa-, he mea e tika ana ki te aroturuki i te taumata o whākōkī ate.

Ko reira antileukotriene whakatupuranga hou o taero, whakaaturia ratou rārangi te raro nei.

Agents e he kau fa'ufa'ufono ko o leukotrienes sulfidopeptidnyh, whakataetae e tino whiriwhiri, me te reversible blockers LT D ₄ receptors. Ēnei taero ngā "pranlukast" "Zafirlukast", "Montelukast."

"Akolat" ( "Zafirlukast")

"Zafirlukast" aka "Akolat" Ko te tino ako o tenei rōpū o matū tarukino antileukotriene. Ko reira ano hoki kaha takotoranga bronchodilator. pumau te pānga hoki rawa he wa roa, ki runga ki te rima haora. taea ki te ārai i te whanaketanga o te tauhohenga te huangō i roto i te take o te inhalation allergen "Zafirlukast" tukanga ko. Kei te kï tōna whai huatanga, me te spasm ārai arahau, whakapataritari nei i te hau makariri, ahipirini, mahi tinana, pollutants. tarukino Hohe, me te faaineineraa "Montelukast" taea ki te whakarei ake i te mahi bronchodilator o β2-agonists.

"Akolat" ( "Zafirlukast") i absorbability pai, tutuki ona kukū tihi i roto i te toto e i muri i toru haora i muri i tona whakahaere. Ko tōna wā hawhe-ora o paku roa atu i te "zileuton", me he 10 haora. I tua atu, kua reira kahore pānga i runga i te paranga o theophylline. Manakohia tarukino hohe kia rānei te haora i mua i te kai ranei i roto i te rua nga haora muri, mai i tino whakaiti i te kai tona kaha absorption. Tikanga nohotahi tino pai.

mutunga

Ka taea te whakamahi taero Antileukotriene mō mate pāwera mō tamariki, heoi kahore i mua i tae ratou i te tau o rua. Ki te awhina o enei rongoā i roto i te tamariki peratia ki Bronchitis recurrent, Rhinitis mate pāwera, huangō ngawari.