Te whakatupuranga hou o raau taero statin: painga, utu, arotake

Kua taero Class statin synthesized rite te tikanga ki te whakaiti i te nui o serum cholesterol, me te whakaiti i tūpono Cardiovascular. Hoki te wa roa kairangahau me taote mahi anake ki taero, "Lovastatin," "Pravastatin" "Simvastatin", "Fluvastatin." I reira synthesized "Atorvastatin" me "Rosuvastatin" - ko te whakatupuranga hou o statins, ranei kaua, te raau taero whai hua tino i roto i tēnei kāwai. Ko reira ano hoki tīmata tēnei wā ki te whakawhanake i hou, e ko te ara ake haumaru, me te whai hua statins, i roto i nei no te tino rongonui ki te "pitavastatin."

āhuatanga pharmacological General o statins

taka statins katoa ki te kāwai o te raau taero e pā pākia lipid i roto i te tinana tangata. Ko te rongoa kikokiko haumanu Chemical Pūnaha Whakarōpū e whakaritea e ratou waehere S10AA me ana ki inhibitors o reductase HMG-ropu mai. Hëoi Mahi o tenei pūmua whākōkī, whakapōrearea e ratou te kōtuitui o cholesterol, serum tino whakaiti tona nui. statins taea ana tēnei mahi ki te whakatutuki i nga nohanga tūtohutia o lipids iti-kiato i roto i te toto.

Ēnei pānga kia taea reira ki tino whakaiti i te auau o te whanaketanga o te tohu atherosclerotic. Hoki ārai taero tona takanga. Ahakoa, ki te he e wātea ana te reira i roto i te pānga nui o statins: ū ai ratou te endothelium o tohu atherosclerotic, i roto i tenei whakaaro, tino whakaiti te tūponotanga o Thrombosis coronary, mahi i te tikanga rerekē atu antiplatelet therapy. Ano, ko te whakamahi ngā o enei moni e āhei atu a tae noa ki te whakaiti i te tūponotanga o te whakaeke ngakau. No te mea kei te tāuta statins i runga i te utu ko reira tino tika.

Ngā statins whakarōpū

He maha ngā huarahi ki te wehenga ki ngā akomanga o taero. Ka taea te kite ratou i roto i ngā o ngā āhuatanga kōtuitanga. Hoki, mai i titau te maimoatanga o ngā statins tohatoha i roto i pota rerekē he whaitake ki te whakauru i te whakarōpū i runga i nga toketaá tūtohutia. rite tenei Whakarōpū o whakatupuranga titiro:

• Ahau whakatupuranga "Simvastatin", "Pravastatin", "Lovastatin".
• whakatupuranga II, "Fluvastatin."
• III whakatupuranga "cerivastatin," "Atorvastatin".
• Whakatupuranga IV "pitavastatin," "Rosuvastatin."

Kua wehea statins katoa ki horihori synthesized i ngā rauemi raw, me te taiao. ngā te whakamutunga "Lovastatin," "Pravastatin" me "Simvastatin". raau taero waihanga Ko te okiokinga:. "Fluvastatin," "Atorvastatin", "Rosuvastatin" me "pitavastatin"

Whakarōpū o statins i pota i runga i te tono kei

akomanga katoa o taero, tae atu i te whakatupuranga hou o statins, mohio wehea ki horopeta iti (8 mg), srednedoznye (10-40 mg) o tiketike (40-80 mg). I roto i te ngā:

• taero tiketike-inflammatory ( "atorvastatin", "Lovastatin" "Fluvastatin");
• raau taero srednedoznye ( "simvastatin", "pravastatin", "Rosuvastatin");
• horopeta taero iti ( "pitavastatin").

whakaata ana tēnei whakarōpūtanga te taea o te whakarite, ki to ratou whānuitanga whakaora. I roto i ngā, tiketike-taero i te pānga i roto i te moni tiketike, i pai nohotahi. drugs Srednedoznye, engari "rosuvastatin" iti pai noatia i pota tiketike, engari i te pānga pai.

statin Srednedozny "Rosuvastatin" taea te whakahaere i roto i te inenga tiketike (80 mg), ki te tika, ahakoa te mea o te whakaiti makona oti o cholesterol katoa, me te iti-kiato hautanga e kore maha te hiahiatia. "Pitavastatin" me e rapu utu i te ūnga i roto i te moni iti, no te mea o te mea nga mōrea o tauhohe kino maha nga wa i raro i taua o nga ritenga o te piha haapiiraa.

Ko te hītori o te whanaketanga me te introduction o statins

Ko tino tautohetia History o statins. I te tīmatanga, Kei te nui raruraru ratou whanaketanga i te kore o te matauranga o te cholesterol pākia me te tūponotanga o te whakawhanake atherosclerosis, i runga i nga taumata o lipids toto rānei. Ano, te tikanga gopoholesterinemicheskie kotahi synthesized ki te tautāwhi i microflora i roto i ngā ahurea o pakete, tikanga ki te whiwhi rongoā paturopi parakore. Opening o mahi cholesterol-e tukupu ana o te maha o ngā matū whakaputaina e harore, a kua whakahohea te ako o statins.

riro ia te statin tuatahi, compactin, a kihai whakaurua ki te mahi haumanu tika ki maha whakaaro taupatupatu e pā ana ki ona pānga. I tawhiti te reira i te ahurea o Penicillium cetrinium. Na, i te ahurea o Monascus ruber ko monacolin taratahi K, arai i roto i te Hui-tanguru 1979. I roto i te Pipiri 79th arai me mevinolin, e timata i muri ki te kawe i te ingoa "Lovastatin". whakamahia tēnei raau i roto i te whare hauora, i muri i te reira i tawhiti synthesized e te whakatupuranga hou o statins ranei.

He rota o ātete whakaaro statins leva te whanaketanga, i muri nei i whakaritea e te reira ki te whakahaere nui-tauine tamataraa haumanu. Ki te rā, ko te nui rawa, me te tino whai hua te ako o Ako Survival Scandinavian Simvastatin. Poroa tona ingoa ko «4S». Kei te tino whawhati i te reira i te taea o mate carcinogenic e pā ana ki te whakahaere tarukino, a whakamatau e ratou te whakamahi tino whakanuia ana tümanako ora me te whakaiti i te pā o pathologies coronary whakapeka.

Rāpopoto mo te painga o statins

A, no te tino whakaiti te kukū tuatahi o te cholesterol katoa o 7.4 mmol / l, statin therapy me ki te whakatutuki i te taumata o te 5.4 mmol / L te mōrea o ngā Cardiovascular mate e 40% i runga i te 5 tau i muri. Kua whakaaturia te maha o te tahi atu rangahau e tukupu ana katoa taumata cholesterol anake e 1 mmol / L i te rima o te whakaiti i te tūponotanga o te Thrombosis coronary me i konei whawhai ngakau patunga ranei.

Whakaaro i nga statins, nga pai me ngā raruraru o e korero te rota o ngaio me tūroro, ka taea e tatou mahino te meka e whai ake nei: Ka taea e koe whakahau taero rite wawe rite tau 40 me te pakeke, me te whakaiti i te tūponotanga o te mate ngakau - he rauhanga kouma o roa ai te ora. A mai ko tino wātea statins utu, kua kï whai hua enei taero, e taea te tango e pokaia he ki ona ake pūtea. O te akoranga, he nui ake te utu i te whakatupuranga hou o statins, ahakoa te taua "Rosuvastatin" I roto i te parau tumu, he reira tino utu mo te manawanui. A ko reira te puka faaineineraa tino ngāwari "Merten".

āhuatanga whakataurite: me ngā raruraru

Aromatawai statins, mo a ki a ratou korero rawa noa. Tohenga "hoki" Ko te āhuatanga o ratou mahi whakaora: whakaiti o te toto cholesterol me hautau iti-kiato, te ārai i te mōrea o ngā whakapeka, me te awhina i roto i to ratou maimoatanga. Heoi, taero pērā i statins, i reira e ano contraindications. He pānga taha, takawaenga tohenga ki te tono.

A, no te therapy ki statins te mōrea o te myopathy. Ia pea takawaenga e inhibition o te kōtuitui o cholesterol, hiahiatia nei te uaua. Ko te tino iti te auautanga o tenei pānga, ahakoa nui haere te reira i te coadministration ki ētahi atu āpiha hypolipidemic. He he ano hoki te mōrea o te māuiuitanga ate mate pukupuku, ahakoa te tūponotanga o te mate taua, e whakaaturia e rangahau tata, tino iti. I te taua kï me te meka i whakapataritari te mate pukupuku i te taha o ētahi atu āhuatanga. No reira, i roto i taka o te "statins" kia rāhuitia contraindications tahi-whakahaere o enei taero ki ētahi atu āpiha e whakatairanga i te hekenga i roto i te kukū o ngā pūtau ngako.

Ko te utu o te whakatupuranga hou o statins

I runga i te whakatupuranga hou o statins utu rerekē, ahakoa he utu te aufauraa i hoki ratou pānga. Ko tētahi atu pātai, ko te anake e taea te tutuki i te hua o to ratou mahi ki te whakamahi o iti analogues piha whakatupuranga mua. I roto i ngā, ko āhua te statin tino noa Generation IV "Rosuvastatin" utu e whai ake:

• 600 moni mō papa o 40 mg;
• 400-450 i runga i papa 20 mg;
• 300-350 hoki papa mg 10;
• 200 moni 5 mg.

Ko te mōkihi kei 30 papa, nui mo te kotahi marama o te maimoatanga, i he āhua i te marama maimoatanga "pitavastatin" utu e whai ake:

• 1 papa mg utu e pā ana ki 700-750 moni;
• Tablet 2 mg - e pā ana ki 1000 moni;
• papa 4 mg - e pā ana ki 1500 moni.

hāngai ana te kōwhiringa i waenganui i "Pitavastinom" me "rosuvastatin" Kei runga wha paearu: tauwehe utu, te tere o te whakaiti o iti-kiato lipoprotein, tiketike-kiato lipoprotein hua tini, haumarutanga. Ko te tere o te tukupu cholesterol, me te whakanui ake i HDL, me te te utu pai titiro "Rosuvastatin", i takahi haumaru atu ko te "pitavastatin."

Muri rua rite te utu i roto i te rite ki "rosuvastatin". Otiia, i reira ko te taea o te whakamahi i te tahi atu, statins iti. Ko te tino öhanga pai kua mua "Simvastatin". Na i whakakapi ia e "Atorvastatin", wā e nei whakakapi e "rosuvastatin" (tona uara ka hinga tika). A, ki te he unaffordable mo nga tūroro statins hou whakatupuranga utu, he mea e tika ana ki te whakaaro i te taea o te rongoā "atorvastatin" ranei "Simvastatin". E te ara, te nuinga o ngā rangahau ki "atorvastatin" whakahaere.

Tohenga i roto i te manakohia o statins kaumātua

I mua, e hiahia ki te whakahau statins ki tūroro pakeke atu i 75 tau matahauroa. Ko te take o te āhuatanga e whai ake nei:

• fariiraa, o te maha atu akomanga o taero;
• hiahia tahi tāpiri tetahi piha o rongoā;
• kore o iti maimoatanga komplaentnost ranei;
• te hiahia o te tūroro ki te hoko ratou statins me ki te whakamahi i ratou no te mea o te kore o te māramatanga o ratou pānga.

He maha o rangahau kawea i roto i ki "Simvastatin" "Pravastatin" me "atorvastatin" whakakitea he hekenga nui i roto i te tahuti nei i roto i te tūroro pakeke atu i 75 tau. Ano, ko ara ki runga ake i taua o tūroro i roto i te rōpū pakeke 55-65 me te 65-75 tau te hekenga i roto i te tahuti nei. No te mea hoki taero o tenei piha haapiiraa (statins) kōrero i te tohunga mārama fakapapau'i he meka.

Ēnei rongoā kia mau ai i muri i roto i te ora ahakoa o ahakoa i reira i whakapeka i mua disorders Cardiovascular. Na tūroro e he take nui ki te whakaiti i te tūponotanga o tona mate i te infarction myocardial whiu ranei tino, e hiahia ana koe ki te matau, ki te he whai hua, me te haumaru i te tarukino, he reira tino utu tango. Rawa riro taua maimoatanga ki statins kua atu wātea, a ka haere tonu rite taua.

Āhuatanga arotake i runga i te whakatupuranga hou o statins

e kore e tohu kōrero Tūroro i aromatawai i te kounga o te ngā statins whānui, no te mea ratou kihai i ite nui rerekētanga i tango i te raau taero. Te whakapai ake kōtaha toto lipid kore e puta i runga i te āhua o te hauora, me te e kore tohu waho. whakaae te reira i kōtaha lipid anake. No te mea ka tupato ki te arotake statin nga tohunga arotake. A e pā ana ki te taka i roto i nei te whakauru kaha he pitavastatin, e kore e taea e tohunga rohe urupare.

I roto i te mahi haumanu i roto i nga Kihi "pitavastatin" no te mea o te utu tiketike, me te mea o te aroaro o "rosuvastatin" me ona arowhānui e kore te tono. I roto i te mau faaineineraa "rosuvastatin", e kua tohua i runga ake, te mahi tere: kōtaha lipid tonu o 1-2 marama. Ko te "atorvastatin" he wā me ngā wā i te hawhe atu. Hoki kano "rosuvastatin" haumaru, mai e metabolized e te cytochrome nga momo e rua. I te kau, tangohia te tenei mōhiohio i te kōrero o tohunga, nui reira he wāhi tino hira i roto i te pai rawa o te statin i roto i ngā āhuatanga haumanu motuhake.

Ko te whakatau whānui o te whakatupuranga hou o statins

Drugs "pitavastatin" me "Rosuvastatin" ko te matatau tino i roto i te māngai o te piha haapiiraa statin, hoki i kohia he tinana nui o taunakitanga. E te tikanga rite ki te hunga o te "atorvastatin" ratou pānga, engari i reira he rerekētanga. "Pitavastatin" me "Rosuvastatin" tukua ki te tae ngā taumata ūnga cholesterol, me lipoprotein kiato iti i roto i te inenga raro atu i te "atorvastatin".

I tua atu ki te painga i runga ake statins whakatupuranga hou he nui, me te ko tetahi atu āhuatanga. Ara, i roto i te maimoatanga o "pitavastatin" me "rosuvastatin" kite he māori nohopuku o lipids toto me te whakakorenga homocysteinemia. He nui rite i roto i te take o te mate coronary whakapeka, a i roto i tūroro ki te mate coronary ma'i tenei, pōreareatanga i te atherosclerosis coronary. Haumarutanga o te whakamahi o statins runga ake i te waikawa ahipirini kardioform. Otiia, i te aroaro o contraindications opani ratou whakamahi ki etahi taupori manawanui (kite. Contraindications General).

tauira waihanga

Medicines kei roto "Rosuvastatin" wātea ana i raro i te ingoa hokohoko e whai ake nei: "AKORT", "Rozistark", "Rozukard", "Rozart", "Merten", "Rozulip", "Roxer", "Rustor", "Tevastor". He kano katoa o enei raau taero "Crestor" i riro te rosuvastatin tuatahi. Drug, te taonga kaha ko ai pitavastatin, rēhita rite «Livalo». E ona arowhānui «Pitavas» me «Pivasta». e kore ratou e tupu i roto i nga Kihi, ahakoa rēhita i roto i te Pharmacopoeia.

whakarāpopototanga

I roto i runga ki te piha haapiiraa o taero pānga me te tātaritanga o te whai huatanga o ratou te whakamahi, kua raihanatia te whakamahi o statins mō te aueue tohu atherosclerotic me te ārai tona riaka. Kei te whakamahia hoki ratou ki te whakaiti i te kaha o te atherosclerosis, e pa ana te kōtaha lipid o serum toto. Ka rite ki te hua, he pono e tika ana i roto i te mafatu tenei piha o taero. Na ko kē te kounga o te statins whakatupuranga hou tikanga whai hua o te ārai o te Thrombosis coronary mate.