Imidazoliletanamid pentandiovoy waikawa: mahi pharmacological, tono, analogues

Ki te mea kua pāngia tō tākuta he "mate viral", te auraa e hiahia ana ki te hamani tika reira koutou. He rōpū tika nui o to tatou hoa tangata whakapono e paturopi - te rongoa pai mo mate katoa. Kia aroha mai, Ko reira he pōhēhē ki te kino i te rota atu atu te raruraru tūturu. He kaha anake ki mate kitakita paturopi, engari he kaha ki huaketo ratou.

Kia pehea te nga mahi tarukino?

He rawa te maha nui o taero ki mahi patu huaketo. Ko tētahi o nga matū tino noa e whai tenei taonga - imidazoliletanamid reira pentandiovoy waikawa.

he kaha ki tukumate momo o rewharewha A me B, adenovirus, parainfluenza reira me āwhina ki matehā mate huaketo syncytial.

Tenei pūhui kaha he tikanga ahurei o te mahi. inhibits te reira i te tukanga whakaputa uri i roto i wheori pata atamira wāhanga me te tairoiro e hoki te hekenga o te kaihoko hou hopuhopu i te pūtau taiao Karihi cytoplasmic.

Kei te hoki whai wāhi waikawa pentandiovoy imidazoliletanamid i roto i te pūnaha ārai mate te tangata, te whakarato i te pānga modulating. Ko te taonga faarahi ihirangi interferon toto ki te taumata o te täkupu whaiaroaro. reira whakaongaonga hoki te tukanga o α-, leukocytes γ-interferonproduktsii, hua i roto i te āhua hāngai o ēnei mahi.

whakakitea tūhuratanga o te taonga kaha e imidazoliletanamid pentandiovoy waikawa whakatairanga te whakatupuranga o cytotoxic lymphocytes mahi. Ano, faarahi te reira i te maha o NK-T-āpiha e whai kaha kē ki te whakangaro tika pūtau puta ki wheori, me te mahi i runga i tukumate.

Ko te painga ko te aroaro o te tarukino i ngā āhuatanga anti-inflammatory. E whakaratohia ratou ki te tämi i te hanga o te kōtaha cytokines, me te te hekenga i roto i te mahi o te myeloperoxidase whākōkī.

pānga haumanu

Imidazoliletanamid pentandiovoy waikawa, he pai arotake o nei, whakaatu ana te muri te pānga haumanu i roto i te maimoatanga o te mahaha me rewharewha:

• whakaiti te reira i te roanga o te tukanga febrile.
• Te whakaiti tohu o te haurangi (whanoke, mamae, ngoikore).
• Whakaiti faaiteraa catarrhal.
• Whakaiti pōauautanga tenei mate.
• Te whakaiti i te wā o te mate.

Drugs ki te waikawa imidazoliletanamidom pentandiovoy

Ka taea te kitea te rongoā te formulations e whai ake nei kei roto waikawa pentandiovoy imidazoliletanamid:

• "Vitaglutam" puehu.
• "Ingavirin" i roto i te puka o capsules.
• "Dicarbamine" pire.

contraindications

Ka rite ki ki tetahi tarukino imidazoliletanamid waikawa pentandiovoy - he tarukino e me whakahaere e te rata haere. He contraindications tenei hua ho'oraa, tae atu:

• I roto i te hapū me te hohipera.
• Tamariki ki runga ki te tau 18 tau.
• Hypersensitivity o wāhanga tarukino.

pānga te taha i te rongoā kei roto i te taonga kaha whakaahuatia taea te whakahuatia i roto i te puka o te tauhohenga pāwera.

whakaratohia ana tēnei pānga e e te tangata kua he te tūtohutanga takitahi ki te imidazoliletanamidu pentandiovoy matū waikawa ngaahi houalotú ranei, e he wahi o te tarukino.

haumaru

tamata ētahi iwi ki te karo i te whakamahinga o tenei tarukino, whakapono e imidazoliletanamid waikawa pentandiovoy - ko te rongoā paturopi. Ko te pohehe tenei tirohanga, mai tenei taonga kaha whakaaturia mahi patu huaketo anake. Whakakorea ake kounga huaina ia o nga pānga taha katoa e te hunga tūturu kōtaha tarukino antimicrobial. Te raau e kore mahi immunotoxic, carcinogenic, mutagenic ranei allergenic waho irritating te wahi kūnatu kahore e heke mahi whakaputa uri e kore embryotoxic pānga teratogenic ranei.

Tohua e te mahi, kaua tiketike o taero e kua tito o imidazoliletanamid pentandiovoy analogs waikawa e kua tangohia waha. E tere whenumi ratou i roto i te wahi gastrointestinal me e te taurite wehea i roto i whēkau me te kopa. Kua muri te hawhe te haora i muri i ingestion o te whakauru rongoa tae tona kukū mōrahi i roto i te toto, a puritia 37 haora. Ko te roanga o te maimoatanga 5 ra. Ia whakahaere o te tarukino te peke o tona ihirangi i roto i te toto, e heke āta i roto i te ra. E kore te te tarukino i roto i te tinana tangata metabolized putanga tonu i nga whatukuhu, me te paru.

āhuatanga fariiraa

He mea nui ki te mau i te talena inenga o te tarukino. Imidazoliletanamid pentandiovoy e āhuatanga analogs waikawa e āhua i te kupu tohutohu taua mo te whakamahi, kia pau waha kotahi te ra i roto i te nui o 90 mg i runga i te wā o 5-7 ra, ahakoa o te kai.

Ko te taa o tenei maimoatanga he kaihoko rongoā ko e tutuki te tōtika rahi, kei ka hoatu i muri i te kimi i te tohu tuatahi o te mate i roto i nga ra tuatahi e rua.

"Vitaglutam" - te puna o te rōpū o āpiha huaketo

Ko te hītori o te tarukino haere hoki ki te 70 o te rau tau whakamutunga. I whakawhanakehia te reira e te rongonui rata pulmonologist Russian Alexander Chuchalin. Kei roto te medicament rite te matua kaha waikawa pentandiovoy whakauru imidazoliletanamid. "Vitaglutam" i whakaurua i raro i te ingoa hokohoko "Dicarbamine" tae noa ki 2008. Tona whakaaro i taua, ki te whakaongaonga tukanga hematopoiesis i roto i tūroro hunga i pehia therapy maimoatanga o te mate pukupuku.

I roto i te 2009, fehangahangai tangata e ki te mate e wehingia ana huaketo - poaka rewharewha, ranei te A / H1N1. I tenei wa, "kua whanaketanga Vitaglutama 'kua tino hāngai. Aleksandr Chuchalin, ko wai i i taua wa te tino rata o te Russian Federation, faaoti ki te whakamātau i tana hanga ki te huaketo rewharewha poaka, me te kua tutuki ngā hua angitu. ka mea ia e te hua kāinga, e hāngai ana nei i runga i imidazoliletanamid pentandiovoy waikawa, "Vitaglutam" whakaatu i te miramira nui nui ki te mate paoro atu te hua ho'oraa American "Tamiflu". Kei te kaha integrated ia ki te genome viral, a ka patua e.

Life New "Vitaglutam" tarukino "Ingavirin"

whakaarohia Chuchalin Gennady Onishchenko, te tākuta parukore tino o te Russian Federation, ki te whakamahi i tana tenenga hei taputapu whai hua i roto i te maimoatanga o poaka rewharewha. Ka rite ki te hua o te mau tamataraa haumanu o te tarukino kua whakahaeretia, i roto i nei whakapumautia reira tona tōtika ki te whakapai kanohi ki ngā mate viral. I hoatu te tarukino he ingoa hou "Ingavirin" a ka rēhita i roto i te rēhita o te rōpū o te raau taero patu huaketo me immunostimulatory.

Kia tenei hua ko te kamupene ho'oraa "Valenta" haere i runga i te hoko, i mana tūtohu ana e te Tāhuhu o te Hauora rite te maimoatanga mō te poaka rewharewha, ka anga ki te whiua ngā pūkete o rongonui i roto i te taupori. Ko te kupu, e nehenehe tatou e te mea e pā ana ki te faitatau "Dicarbamine" - imidazoliletanamid pentandiovoy waikawa - "Vitaglutam", e ko, i roto i te meka, kotahi me te rongoā taua.

E tano ia tapao i te meka i haere "Ingavirin" i runga i te hoko i roto i te tau 2008 i hanga kahore tamataraa haumanu tonu. Ki te āwhina Onishchenko i 2009 whakatere tamataraa haumanu i runga i kiore taiwhanga i whakaritea. Ano i roto i tenei hui, tae e pā ana ki 100 tūroro whai wāhi. I runga i nga hua o te rōpū ako arahina ki Chuchalin mutu e "Ingavirin" i roto i te haora tuatahi 48 i te timatanga o te mate whakakitea tukumate mate pai āhua tiketike. kitea Ko tōna mahi i roto i te whakaiti o te wā febrile, whakaiti te tāoke i roto i nga kararehe taiwhanga me tūroro, me te whakaiti i mau faaiteraa catarrhal.

Na reira, i reira he kahore take ki te whakaaro e pā ana ki imidazoliletanamid waikawa pentandiovoy e he makanga - kï tona whai huatanga te hauora.

"Dicarbamine" i tenei ra

I tēnei wā, katoa taero e toru i runga i te waikawa pentandiovoy pūtake imidazoliletanamida te tīariari arumoni me te tūnga rite ritenga ki tahi i te tahi.

"Dicarbamine" tūtohutia hoki te whakamahi i ngā tūroro ki te aroaro o te pukupuku mārere. I tua atu ki te whakauru matua kaha, kei reira te waiu huka, talc, māngaro potato, stearate konupora, otinga colloidal o takawai hāorarua me waikawa nenehake.

"Dicarbamine" kua te pānga haumanu e whai ake nei:

• Whakatere o neutrophil pārōnaki me te matuatanga mahi.
• Gematoprotektsiya ki te hahau myelosuppressive.
• Whakaiti i te auau o te tupu, me te tohu o te neutropenia paitini, leukopenia whāiti.

tūtohutia ana tēnei faaineineraa te ki te tono i waenganui i ngā akoranga o te hahau.

He kitea i muri i 21-28 ra o whakahaere o ia rā o papa kua tōna whai huatanga.

He horopeta kotahi o te rongoā - 100 mg (1 papa) - tango 5 ra i mua i te tīmatanga o te hahau, ka tonu puta noa i te maimoatanga. "Dicarbamine" kua te taonga ki te whakatairanga me te roa i te mahi o te anticancer taero cytotoxic, ki te whakaiti i te pānga paitini o te cyclophosphamide me konukawata hāngai taero, ka hua ano i roto i ngā tukanga noa o te hematopoiesis.