Interferon tangata - ngā āhuatanga koiora

kitea Interferon tangata i roto i 1957 e rua pūtaiao Isaacs me Lindemann. Kua mihi ki tenei kitea he tikanga hou mo te tiaki o te pūtau tangata kua whakapumautia ki mate viral. i incubated kaituhi huaketo rewharewha Heat-inactivated i roto i hua, horionalantois hanumi me te kitea e inhibits te supernatant te tupu o te huaketo kaha i runga i horionalantoise. ingoa o te wāhi i roto i te homogenates i interferon, me tona taonga koiora ahurei mō nga tau maha i whakapono antivovirusnuyu tiaki. I kitea te reira e te kaihanga o interferon he pūtau o ngā kopa tangata me te kararehe. piri Ko tōna hanganga e wheori, huakita ahua iti, harore pathogenic, hātare, mitogens mana waerau waihanga. E taea e ki te kaha ai interferon kōtuitanga i roto i 3-4 haora i muri i heki huaketo Leukocytes.

Me kï reira e kua roa kua mohiotia te āhuatanga o te pokanoa viral. Kei te hāngai te reira i runga i te kaha tiaki tangata ki te mahi o te huaketo huri ki te awhina o ngā āhuatanga o te ātete nonspecific, ki te i te wa ano i mua ranei i whiwhi i te tinana kotahi iti mōrearea huaketo. Te tahi mea rite tenei, e ko, kitea te āhuatanga o te pokanoa te roto tukumate kitakita i roto i te akoranga o ratou pāhekoheko. I kitea te reira e taea tetahi momo o tukumate tautāwhi i te tārua o tetahi momo, a ko te kupu te huri meinga ratou te akoranga ki te mate. Kei te whakamatauria te reira e ka te tangata i pangia, brucellosis kararehe ranei, whakawhanake ratou wātea i te mate ki te mua. pokanoa whakaahuatia i waenganui i nga huakita brucella me tularemia. He he take ki te amo i taua te pokanoa o nga huakita hua he inhibitor e poraka te pūtau tairongo i roto i te tonotono-kaiao e hanga tikanga kino mo te oraraa o tetahi o nga tukumate whakataetae.

E ai ki te raraunga tata, i reira e toru ngā momo o te interferon (gamma-ārai, fibroblast peta me te Arepa leukocyte interferon), e rerekē i roto i te takenga mai, tinana me ngā āhuatanga koiora. Me mea te reira e kawea te pokanoa i waenganui i wheori te roto ki te āwhina o te inhibitor motuhake synthesized nei e pūtau huaketo rauropi.

Whakamatauria e interferon tangata - he rōpū o pā peptides kaha biologically, e kua hanga e i roto i te pūtau i muri i whakaongaonga i whāpoapoa rerekē. Ko te kukū o te interferon e he taea ki te pehi i te mahi koiora o huaketo rerekē i roto i te tinana, rerekē tino kaha. Te nuinga tairongo ki te mahi o te interferon whakamatauria wheori he he anga me lipid waho wāhanga (miksovirusy, arboviruses, koroputaputa huaketo), me picornaviruses mea adenoviruses kowaiwai o te kōpaki waho me ko atu ātete ki tenei take. Heoi, i reira he okotahi ka wheori he tenei kōpaki, nui haere whakaatu ātete ki te mahi o te interferon (huaketo herpes).

interferon tangata

Ko te hiringa matua mo tona hanganga maha whakaaro te kătahi o ke pūtau waikawa karihi, e whakaiti i te toenga ira noa o te rōpū ngā o ngā pūtau. He faaitoitoraa pai te mahi huaketo waikawa karihi i roto i ngā pūtau kararehe whai tuaiwi, ahakoa ētahi atu waikawa karihi taea te mahi kia rite ki whāpoapoa o interferon. I roto i te wāhanga o ngā pūtau koiora e kua āhuatanga e pānga interferon, takaro he wāhi nui e endotoxins o huakita karamu-kino, me te hoki lipopolysaccharides me polysaccharides, i roto i pirogenal ngā, prodigiozan. whakaputaina Interferon e mahi a te tangata i raro i te mana o phages RNA me huaketo, e pai i tiaki i te pānga inhibitory o ribonuclease.

Ki te whakaaro ki te āhuatanga o te interferon, ia, i roto i te rerekē ki te inhibitors mohiotia mahi i runga i te huaketo tika pānga ratou i roto i nga pūtau tairongo, hanga ātete ratou ki uri viral. Ki taea interferon whakaatu pānga patu huaketo, kia waiho pūtau tairongo kōtuitanga ratou wenua o te RNA pūtau me pūmua pūkoro.

I maoro, rite te kaihoko huaketo whakahaere "tangata interferon Alfa recombinant 2". e pā ana tikanga mahi patu huaketo te ki te hanga o tikanga tiaki neinfetsirovanyh pūtau huaketo. Ka huri tēnei nga āhuatanga o kiriuhi pūtau, e ārai te kătahi o te huaketo ki te pūtau.

Ko te āhuatanga koiora ngā interferon momo pū, e te tikanga faaiteraa whiriwhiri o mahi i roto i te tinana o ona momo huirua. Hei tauira, interferon hua pūtau kukune heihei, e kore e tiaki kiore ranei ētahi atu kararehe, me interferon whakaputaina e leukocytes tangata, e kore mahi i roto i nga kararehe. E kore te mea tino tenei taonga, me te, i roto i ētahi wā, kia takenga heterologous interferon kaha i roto i te tinana o tetahi momo.