Kanisā myeloid whakapeka

kanisā whakapeka - he mate o te pūnaha hematopoietic, e hāngai ana i runga i - te tini mutunga o ngā pūtau puku, e ko tona tïpako morphological. Kei te wehea kanisā myeloid whakapeka i runga i FAB whakarōpū ki kōwhiringa whitu. Ko te pūtake o te whakarōpūtanga - te taumata o pārōnaki o te pūtau e tohu i te kanisā tïpako. ahu Myeloblasts clone puku te i pūtau kakau, e he nehenehe o te whakaputa koroni tipu maha o myeloid pūtau, megakaryocytes, erythrocytes, macrophages.

Ko te tino pinepine kitea rerekē M0-M3. Ko te pūtake o te tuatahi e rua - pūtau kahore pārōnaki. differentsirovanokletochny - kōwhiringa M2. āhuatanga M3 ahua promyelocytic e pūtau rerekē ki purapura Rapa. M4 ko M5 - kanisā myeloblastic me monoblastny. M6 - erythromyelosis, ki nui haere tini o ngā pūtau erythroid. M7 - kanisā megacaryoblastic. O nga kōwhiringa katoa, e kua aroaro ki te kanisā myeloblastic whakapeka, he tino pai ka M0-M2 waitohunga.

kanisā etiopathogenesis

He aha te mea koi kanisā myelogenous. Ko te mate - ake kaha o ngā pūtau ki irakētanga e tika ana ki te mahi o ngā āhuatanga o waho (radiation, wheori, matū matū) me te predisposition ki pāhekeheke ira o te huinga ira. Nā tēnei, i roto i ngā pūtau puku ahei o te wehenga mutunga. ahua ai ratou he ki tou e, i roto i te tahuri, i irakētanga toutou homai ara ki subclones.

E tonu hua pūtau puku i roto i te hinu wheua wheua, me te akina e totohu hematopoiesis iroriki noa. Āta, haere ratou ki te toto piringa, me te metastasize ki whēkau, hanga aronga atu o te hematopoiesis rerekē. Whakawhanake kanisā myeloid ki āhuatanga pikitia haumanu hoki ia.

Hauora kanisā myelogenous whakapeka

No te mea o te tauwhatinga o te hematopoiesis noa i roto i te tūroro ki te anemia, te maha o neutrophils pakeke me platelets heke koi. whanoke māharahara. ngoikore. He tohu o te toto: pakaruhanga toto i roto i te kiriuhi kiri, me te mucous, nui haere toto i roto i paheke, nosebleeds. Mamae i roto i te wheua, taikiri tetere o ngā rōpū rerekē. kōateate nui ake, me te ate. Nā disorders mahi o leukocytes, whakaiti wātea i te mate whakapeka rerenga kanisā myeloblastic mate rironga. ia maha faaite angina nui.

I roto i te wāhanga i muri mai kia piri tohu o te kore tākihi me tohu neurological.

I roto i tona rere toro whakapeka kanisā myeloblastic taahiraa faaiteraa tohatoha, murunga, matahoki. I roto i te take o te maimoatanga whai hua mutu reira te atamira kāpeka. Atamira o te mate āhuatanga e etahi tohu haumanu me te toto pikitia, me te wheua wheua.

tātaritanga o te kanisā

hanga whakapeka kanisā myeloid e rangahau cytochemical pūtau e tohu tona tïpako me immunophenotyping - tohu myeloid whakatau. homai tikanga morphological mo te rapunga o ngā pūtau hau i roto i te whakatau i te momo o te kanisā ko te uara tohu, ahakoa tonu ratou ki te oaoa i.

whakamahia ētahi wā tikanga tohuira i runga i polymerase chain reaction. Kei te whakamahia te reira ki te whakatau i te mau faaiteraa wäriu o te mate i roto i te tūroro i roto i te murunga.

Whakapeka waitohunga kanisā myelogenous iti pai atu i te waitohunga o te kanisā lymphatic whakapeka. Whakatika ki te 75% o nga tūroro ki te maimoatanga tika tutuki murunga. He he taunakitanga o te whakaora o te 20% murunga tutuki ki tonu maimoatanga kaha. Kua whiwhi nga hua fakalototo'a i te wheua wheua transplantation.