Mahi peroxisome. Zellweger syndrome

I teie mahana te ani manihini matou ki a koutou whakaaro peroxisome mahi. He aha te uara i ratou i roto i te whare herehere? utu ano matou whakarongo ki te aha e taea te kitea te mate ki te awhina o tenei organelle.

Kua i roto i te omuaraa, he reira mārama e te peroxisomes - organelles reira. Te pūtau, i roto i te tahuri, he wahi o te kaihoahoa mātanga mīharo o katoa e haaati nei ia tatou. Ahakoa te tangata titoa te o pūtau, o nei i reira he he tokomaha rawa nui. Na hanga te pūtau kei te ake o nga wahi noa iti, engari tukua ratou ki a ia te ārahi i te ora motuhake, e ko, ki te whakakotahi me te waihanga hanganga matatini e kore te mea e tika ana. He tauira o tenei, ko te mea pūtau-tahi māmā, e pea rongo koutou i roto i te mau haapiiraa koiora i te kura.

I mua i whakarārangi tatou, ka whakaahua i te mahi peroxisome, e ti'a ia tatou ki te matau he aha te mea te reira a pehea mahi ratou.

peroxisomes

Ēnei organelles puta vacuoles rite iti, ko to ratou rahi i raro 1.5 micron. Peroxisome karapotia e te membrane kikokore, a wehe ai nga microgranules roto, i te taiao ā-o te pūtau katoa. He aha e taea e kitea tatou i roto i te organelle? He ko te matua, kua huaina hoki a reira i te nucleoid. He mea nui ki te mahino te meka e tenei wahi o peroxisomes e kore e pā ana ki te hanganga karihi huakita nucleoid ranei. Kaua e whakapoauau enei ariā. a ko reira maha kia te hanganga kitea mimicking tioata rohe nucleoid. E hanga e ratou i fibrils me ngongo. Ko te matua o tenei organelle wehea i te peroxisomes, roto uratoksidoza roto reira. Tenei Ko tetahi o nga whākōkī. Na whakaaro tatou ki te whakaaro i te mahi peroxisome i roto i te pūtau. Ko te aroaro e, he titiro i te hanganga.

hanganga

Na ka korero matou ki ta peroxisomes, hanganga me ngā mahi (kite tepu) Ka hoki te whakaaro e tatou. Hei timata ki te hoatu e matou he hoho'a i roto i te puka o te tepu. Next, tuhituhi atu i roto i te taipitopito i te hanganga me te mahi o peroxisomes. Ka taea te hanga i te ripanga e tatou, engari rato reira ki te mōhio e te kopu peroxisome me ngā o te nucleotide.

Matrix 15 Kei te whākōkī peroxisome. Kia titiro a i etahi. Miramira te nui tino o ratou e:

• peroxidase;
• catalase;
• oksidoza;
• uratroksidaza.

A he aha te mahi ka mahi te nucleotide? Ko tōna tūranga, ko te ki te whakawhāiti te hunga taua whākōkī. Kia titiro a ki te tukanga o te hanga peraksisom. pihi ratou i te EPS, kia taea e matou te mea e te rohe o te hanga o tenei organelle - he CSE. E hua whākōkī i roto i:

• EPS;
• hyaloplasm.

Tenei he mea nui ki te whakamārama i te meka e te membrane, ahakoa kikokore, engari reira e kore e tomo noa nga katote me te iti substrates taimaha rāpoi. Na ka taea e tatou whakaaro te mahi o peroxisomes. Tīmatanga i tēnei organelle ko reira o faufaa nui mo te pūtau.

mahi

He mahi Peroxisome e whai ake:

• piti hāora o ngā matū waro;
• ngakongako hāora waikawa;
• plasmalogens biosynthesis;
• biosynthesis isoprenoid i roto i nga kararehe;
• biosynthesis o cholesterol;
• NDR2 pūmua localization;
• ture o te mumura pūnahanaha;
• āwhina i roto i te tukanga o te respiration i tipu ngā pūtau, a na i runga i.

Ko te tino roa tenei rārangi, no te mea kahore e ano i matau tino etahi mahi. Na tatou whakahere he iti ake ki te kōrero e pā ana ki te kōtuitanga pūmua. He mea nui ki te mohio e roto i enei organelles wahi pērā i:

• DNA;
• ribosome.

Nä, puta te ariā pūmua i roto i te karihi. Next Ko te kawemai o te taiao ā-o peroxisomes. Nahea te matua o te kawemai? Na roto i te whai wāhi tohu C-kāpeka. Ko te tino poto te raupapa o tenei aronga, arā, o te 3 ngā toenga waikawa amino.

Ko te uara i roto i te whakamātautau haumanu

Kua whakaaroarohia e mātou i roto i te wāhanga o mua, i whakamana mahi e peroxisomes. Na he iti e pā ana ki te organelle ūnga raraunga haumanu. Na tatou kōrero he iti e pā ana ki te mate ka karanga - Zellweger syndrome. Ko te tino he mate nui tenei, e meinga ana e ia e te takahi o te pūmua kawemai. Nā tēnei, peroxisomes kau, te pūtau me te rauropi rite te katoa kitea raraunga organelles kore whakapeka. Iwi e mamae i enei disorders i fifi ki te mahi o te tahi mau tinana nui konei ngā:

• roro;
• ate;
• whatukuhu.

E takoha tamariki nei e whanau ki tenei syndrome kore e taea e ora i te wa roa, me te ki te waiho i to tatou ao i muri i te noho poto rawa. e pā ana te mate te ki te irakētanga o te organelle. Ko reira ano momo taea, me te iti iho kino o te mate.