Waikawa Valproic: tohutohu mō te whakamahi, analogs me arotake

waikawa Valproic (konutai valproate) no ki te rōpū āhua hou o anticonvulsants, rere ke i te hunga e whakamahia ana i mua antiepileptics e rua te hanganga matū me te parau tumu o te mahi.

whakaahuatanga o te taonga

synthesized tēnei matū i roto i 1882, i roto i te waikawa valeric orotahi Dr. W. Barton. Kei a ia ko 2 rōpū o tapahia. No te tekau tau maha, whakamahia waikawa valproic te anake i roto i te taiwhanga rite te whakarewa e mangere o ngā pūhui matū waro. i kitea Protivosudorzhnye ona āhuatanga e te whiore.

He wai, me te mārama i te pāmahana rūma waikawa Valproic. Ko te kupu ko reira, e nehenehe o te tauhohe i ki te turanga pērā i te konutai waihā valproate konupora ranei ki te hanga i te tote, i te mea he taonga mārō. Ko tēnei rauemi, i roto i te meka, he waikawa 2-propylvaleric me ona tote konutai. Rerekē atu antiepileptics, tohu te reira i te pūhui hauota-free. Ko te tikanga o te mahi o tenei waikawa me ona tai, e pā ana ki te mana motuhake i runga i te pākia o te waikawa kama-aminobutyric, ko he inhibitor o te pūmua whākōkī transferase.

Formulations tito nei o te waikawa valproic, a tukua iho tona takiri te tauhohenga excitatory wāhanga nekeneke o te roro. Ko e tika ana ki te meka i te taonga whakanuia ana te ihirangi o te waikawa kama-aminobutyric i roto i te hanganga pūnaha io tenei. Valproic waikawa, e tohu whakawākanga o tona whai huatanga anticonvulsant i te maimoatanga o tikanga e pā ana ki te rōpū o waikawa ngakongako.

Āhuatanga o te waikawa valproic, ona analogues

Valproic waikawa, e whakaahua ana i te ako ki ona pānga matatini i runga i te tangata, hua te i raro i ngā ingoa rerekē. Ko te taero pai-mohiotia, e ngā he taonga e ko "Depakine," "Konvuleks", "Konvulsofin", "Orfilin", "Deprakin", "epilation", "Everiden", "Enkorat", "Apilepsin", "valparin XP "," Dipromal ". Ko te puka inenga oti kia ai taua mea i roto i te puka o te waikawa tona konutai ranei tote, e mohiotia ana ko te konutai valproate. E kore te te mahi o tenei tarukino iti. Valproic waikawa, analogues o nei e whakarārangitia i runga ake, tangohia waha tonu i muri i ngā kai. taero katoa kei roto i te reira, e hohoro riro. Kua muri 2 haora puta te waikawa i roto i te wē. E pai ana te ô i roto i ngā ārai kiko. tohu wäriu o te taonga i whakaritea i roto i te inu cerebrospinal me i maha taiao ā-atu. Ko tōna kitea i roto i te waikahu (waikahu) i roto i nga wahine hapu.

parau tumu o te mahi

taea pehea mahi waikawa valproic? Tohutohu ki tenei tarukino kore e hoatu i te whakahoki pau ki te pātai o te mea ko te huarahi o tona mana whakaora. Ko e tika ana ki te meka e kore e ano tino tohunga tirotiro ona pānga i runga i te huringa i roto i ngā āhuatanga konutai hongere tenei. I roto i tenei take, ngā waikawa valproic te i roto i te rārangi o ngā rongoā e mea faufaa, me te nui hoki te iwi.

Pānga i runga i te tangata

E kore anake whakamahia mō te waikawa valproic haurangi. i runga i te whakamahi o tenei aratohu rongoā tohu reira e kua reira pānga anticonvulsant kore anake. whakapiki i te reira i te tūāhua me te āhua hinengaro o te tangata. Tohunga mea e pā ana ki te aroaro o te tranquilizing wae waikawa. Rerekē ētahi atu hua o tenei ahua, te whakaiti i te reira manukanuka, kahore meinga mioleraksantnogo whakarokiroki ranei. He tika ki tona mahi i runga i membrane postsynaptic tenei. Ko te kupu tāmia tukanga hihiko te tuku karere.

Hoki ngā puka iti o te haurangi maha iti ki te tango waikawa valproic tetahi o ona analogs ranei. I roto i te wā atu nui ngā te tarukino te ki atu taero antiepileptic.

Valproic haurangi waikawa

whakamahia tēnei faaineineraa i roto i ngā momo rerekē o te haurangi. Ko te kupu e hāngai ana tona fariiraa i runga i te rata tauira whakapumautia. Valproic waikawa, tohutohu hoki te whakamahi i tohu tona whai huatanga i ngā momo rerekē o te mate, whakamahia te i roto i ētahi wā i roto i te pota rerekē. Ano, Kei te maha whakaritea ai, me i haurangi ngahunga.

Whakamahi o te tarukino

Valproic waikawa, te ako titau te whakarite o te tarukino ki ai to koutou tākuta me te pipiki tino ki regimens tarukino, tono i roto i ngā take pēnei i:

• ārai o pōauautanga ngā i roto i te haurangi;

• ngā āhuatanga takiri ahu i roto i etahi mate o te CNS;

• aroaro o te tic io;

• ma'i härukiruki-fakalotofo'í kore he Nireaha ki te maimoatanga me taero kei roto lithium,;

• ngā āhuatanga takiri ahu i roto i te tamarikitanga.

waikawa Valproic me formulations kei roto i te reira, me kia anake te mana e te rata haere. i muri anake i te rangahau e tika ana katoa me te mātanga aromatawai manawanui ka taea ki te whiriwhiri i te horopeta haumaru, me te whai hua o te tarukino.

Puka tuku

Valproic waikawa, te puka tuku he rerekē i, e Kikī rerekē ngā kaiwhakanao e whai ake:

• Papa, papa pani, wairewa i roto i te piro. Kei roto ratou 150, 200, 300, 500 waikawa valproic mg (konutai valproate).

• Tōpata 150, 300 mg.

• Medicine (tirikara) kei roto 50 300 ranei ml o te raau taero i roto i te 1 ml.

Hototahi ki ētahi atu taero

Valproic waikawa ahei o te whakarei ake i te pānga o ētahi atu anticonvulsants me tikanga protivoelepticheskih, neuroleptics, antipsychotics, pōuritanga, me te waipiro. A, no te riro koutou e kore e taea e tenei rongoā inu ava. Valproic analogs waikawa o te raau taero, waikawa salicylic me anticoagulants i te pānga inhibitory i runga i te whakawhāititanga (rōpū) platelets. No te patia i roto i te whēkau te tere whenumi te medicament ki te bloodstream. Ko te kupu te whakamahi o te waikawa valproic i roto i ngā ki tetahi kai ahua whakaiti tona whai huatanga.

pānga taha

Ko te medicament ētahi wā ai ngā pānga taha pērā i whakapairuaki, ruaki, mate o te hiahia, me te pakeke o te mamae i roto i te kopu, korere. Hei whakatikatika i ēnei tikanga tono tapo'ii antispasmodics ranei. Ka taea e waikawa Valproic meinga te whārua whānui, me te rohirohi, na te uaua whakaritea reira ki te iwi mahi i roto i te mahi ā-tinana, me te hinengaro ma'ongo'onga. Te fariiraa i te tarukino ētahi wā arata'i ki disorders o te pūnaha io, e faaite mai ratou i roto i te puka o te faaati o wahi, whakapakoko ritua me nga whakaoho ataata, te momoe, ānini, whanoke, rōpū,, tau'a, me āhua fakalotofo'í.

I roto i ētahi wā, te rōpū o tenei tarukino arata'i ki te mau hopearaa e whai ake nei: he heke me te hua i roto i te taimaha tinana, te ahua o mate pāwera, rangitahi mate makawe, kōtītiti paheketanga, huringa i roto i te hemogram. E whakaaro onge, engari tino nui ngā pānga taha o tenei tikanga te whiwhi ki arā o te ate repe taiaki ranei, whakaiti upoo- toto. Ko te nuinga pea pānga Hepatotoxic ka te fariiraa i tenei tarukino wā kotahi ki te clonazepam, phenobarbital.

A, no te whakamahi i te waikawa valproic Me mahara e roto i tūroro mate huka e taea ketia reira te hua o te tātari o mimi, te whakanui ake i tona ihirangi o tinana ketone. Hoki te ārai o ngā pōauautanga i roto i te maimoatanga whakatau wā te ihirangi i roto i te toto o te bilirubin, whākōkī ate, tatau mōtepe.

contraindications

Valproic waikawa, e kua hokona taero i runga i te counter kahore whakahaunga, he contraindications nui. Ko ētahi o ēnei:

• pōrearea o te repe taiaki me ate;

• porphyria;

• hemorrhagic diathesis;

• idiosyncrasy;

• Ko te huatū tuatahi o te haputanga;

• wā kai (haere te tarukino ki te waiu uma).

I roto i te II me III huatū o hapūtanga, whakaritea tenei raau i roto i pota iti me mo take nui anake, no te mea e whakawhiti reira te ewe me te taea pā te tamaiti e parauhia te.

A, no te fariiraa i te waikawa valproic kia āta aroturuki i te mahi mana ate toto upoo- me mōtepe whakahiato. I roto i te therapy, kia whakamahia tenei wahine tarukino nei e kaha moepuku, ki te ārai hapūtanga, te tikanga tino pono o te ārai.

tono o te kaupapa

Teuteu kei roto tenei waikawa, kua tangohia hoki kaupapa rerekē. E tīpakohia takitahi pota tino pai. pānga te kōwhiringa o inenga talena te o te manawanui huru, te taimaha me te tau. I roto i te nuinga o te wā, wawe i roto i te akoranga i roto i ngā pakeke me ngā tamariki kotahi neke atu i te 25 kg, whakahaeretia i 10-15 mg / kg ia ra. I muri nui haere horopeta wiki o te raau taero e 5-10 mg / kg, mau mai i reira ki mōrahi - 30 mg / kg. Ko te horopeta rā mō ngā tamariki - 20-50 mg / kg. I roto i te whakawhitinga ki te maimoatanga me te maimoatanga waikawa valproic ki ētahi atu taero anticonvulsant iti te āta. Ko te horopeta mōrahi o te waikawa valproic kore e waiho ki runga ake i te 50 mg / kg ia ra.

He ngā momo o tuku o te tarukino. whakahaere rō-uaua tā te fariiraa 400-800 konutai valproate mg ia ra. I roto i te akoranga o te therapy he tika ki te whakatau i te taumata o te tarukino i roto i te toto. E ai ki tätari, kia hanga whakatikatika ki te talena maimoatanga.

Tohu o te kaupapa:

• tamariki pakeke 3: I roto i te wiki tuatahi o te inu 150 mg o 1 p. he ra, i roto i te tuarua - 150 mg o 2 p. ia ra, me te tuatoru - ki runga ki 150 mg o 3 p. ia ra.

• tamariki 3 - 10 tau: i roto i te wiki tuatahi o te tango 450 mg, i roto i te tuarua - 600 mg, a i roto i te toru o - 900 mg ia ra. E ai ki tetahi atu te fariiraa i ara iahiko 300, 450, 600, 900 mg ia ra, aua, i roto i te 1, 2, 3, me te 4 wiki.

• I muri 10 tau: i roto i te wiki tuatahi o te inu 600 mg, i roto i te tuarua - 900, i roto i te toru o - 1200 mg ia ra. E ai ki tetahi atu te fariiraa i ara iahiko 300, 600, 900, 1200 mg ia ra, aua, i roto i te 1, 2, 3, me te 4 wiki.

Hoki tūroro peratia mua ki ētahi atu anticonvulsants, valproic waikawa whakahaere i roto i pota iti. I te wa ano heke te maha o te tahi atu tikanga te. Ko te horopeta oranga ano hoki mo ngā pakeke - 900-1200 mg. Valproic Waikawa, papa me capsules i whakaritea te i muri i anake 10 tau, tangohia i roto i te 2-4 werohanga. Hoki ngā tamariki tino pinepine whakaritea rongoa tirikara ranei ki tenei tarukino.

"Depakinum" (waikawa valproic)

I te hoko i reira e rerekē taero ki te waikawa, engari ko te kotahi o te rongonui tino "Depakine." I roto i pharmacies, i reira e rave rahi ngā momo o te rongoā: "Chrono", "300 Enterik", "granules Hrononosfera" me etahi atu. He paku rerekē katoa ihirangi whakauru hohe me te puka ratou. "Depakine" whakaritea hei anticonvulsant me tarukino tūāhua-aueue. Kei te pai te pumau te reira i roto i te maimoatanga o te haurangi, disorders pourua, haurangi toniki-clonic whānui, myoclonus, korekore, pāhoahoa migraine. Kei te whakamahia hoki te reira mo te maimoatanga o te mamae neuropathic. Tata nei, whakawakia te tarukino rite he tarukino ki etahi momo o mate pukupuku, me te HIV mate.

Valproic taupuni waikawa

I roto i te raau taero waikawa valproic "Depakine" me ona analogues kei roto i te tono tiketike. Ko e tika ana ki te meka e te mea he pānga auroa tenei. Ko te whakamahi o tenei faaineineraa arata'i ki te whakaiti i roto i te auau o te takanga o hukihuki takiri. reira te whakaiti hoki ratou pakeke me whakahaere te rere. "Depakine" whakaiti i te mōrea o te whakawhanake pōauautanga atu nui.

kawea tukanga metabolization waikawa valproic pūtau ate. A, no te fariiraa i te matū tikanga hawhe-ora ko āhua 6-8 haora. Ka taea e taero Modern mau tonu te kukū whakaora o te taonga kaha i roto i te tinana ki te 16 haora. Ko te tere o te excretion o te waikawa valproic tei te nuinga i runga i te mahi ate. Valproic waikawa, e arotake e pā ana ki te pānga pai atu i runga i ia manawanui i runga i tona ake. Ko e tika ana ki te meka i nga tinana he ahurei, me te taea te tango i tenei mea ki te tahi mau ine i te täkupu tenei.