"Alfa Epoetin": ā-ako, arotake me analogues

taumata Uncharacteristic o kukū o pūtoto - tetahi o nga tohu o te anemia. I roto i te meka, he kore he tātaritanga, engari tohumate anake e ko te faka'ilonga o maha mate tenei. Ko te ahunga whakamua o taua mate kia tohu i te lesion tuatahi o te pūnaha toto.

Ko te stimulator o erythropoiesis, mohiotia i raro i te ingoa kore-kamupene ao rite "Epoetin Alfa" tohutohu mō te whakamahi rite te tūnga kaiwhakahohe mahi nui e whakahaua āhuatanga pharmacological ki te maimoatanga me te ārai o anemias o etiologies rerekē. e kore anake e tauturu tika whiriwhiria inenga ū hanganga wae toto, engari ano hoki kua he pānga pai i runga i te uaua ngakau.

puka Tuku me te hanganga matū

He wātea te hua rongoa i roto i pharmacies i te puka o:

• pūwero tuku i horomata ki te horopeta tatūkē (whakarato hoahoa mō ngira tiaki atu);
• otinga i roto i te oko.

hoatu te te tūranga o te whakauru pŭpŭ tauturu:

• wai injectable;
• dihydrate pūhaumāota me te konutai hydrogenphosphate;
• polysorbate-80.

Ko te mahi koiora o te taonga i roto i te pounamu e taea e rerekē. I roto i te nuinga o te wā, he mano ranei e rua mano Units International ia 0.5 ml o te wai. Heoi, i reira e hoko ano atu kaiwhakahohe puka, tae atu "epoetin Alfa" 10,000 RW. / 1 ml.

Ko te tikanga o te mahi pharmacological

He ōrite ki te erythropoietin tūturu āhuatanga koiora me te immunological o te hua synthesized. Na reira, rongoā rawa tōtika Kōpeke nga tohu o te anemia, a ka papaki te toto rite te glycoprotein angamaheni. Me mea e ahau e "Alfa epoetin" matua hāngai ana ki te whakanui ake hematocrit me ngā taumata pūtoto māori. Tona "mahi ngakau," me te te huru o te wae ki te whakapai ake i te rere toto ki te kopa ko iti korerotia.

-Wā hawhe:

• e werohia rō-uaua - wha haora
• ka patia subcutaneously ki - e pā ana ki te ra.

Ko te kukū mōrahi o te matū hohe i roto i te wē ki te kia tūmanakohia i muri i 12-18 haora.

motuhake e pharmacokinetic

Kua whakaaturia Studies e te Kereru te raau whakaahuatia te hanganga o paturopi i roto i te aratau "hohe", me tona faufaa pharmacological i roto i te tukanga o te wheua wheua kakakīrehe he tata ki te kore. Ko te pūmua hautanga medicament "Epoetin Alfa" ngā o e pā ana ki 165 waikawa amino (58% o te katoa taimaha rāpoi), ka kitea tenei i roto i te tohu, me te kounga o whakaawe nga wae te wehenga / pārōnaki o ngā pūtau tupuna.

Tukuruatia whakahaere rō-uaua (i roto i te ngaro o pathologies tākihi) e kore e arahi ki te haaputuputuraa o te taonga kaha; tamariki i raro i te tau o 12 tau he roa pea o T1 / 2 wā ki runga ki te 6 haora.

Tuhinga hoki

"Alfa Epoetin" e tūtohutia hoki te whakamahi, ki te:

• anemia pāngia rite te mate o te mahi hematopoietic, e tahi mate pukupuku (tango te wahi ki te hei pukupuku kore-myeloid);
• mana'o te manawanui te hiahia mō te tātari toto auau ranei tātari peritoneal ;
• Ko te pātai o te whakahaere i pokanga matatini ki te whakamahi o e huhu toto allogeneic;
• huaketo te manawanui kei ki HIV me te whiwhi therapy runga i te pūtake o te zidovudine;
• titau Kautetanga ārai.

Te talena dosing tino pai

Hoki te faaineineraa "Alfa Epoetin", te tātai mō te kōwhiringa takitahi o te horopeta ia rā. Heoi, iti te kupu tohutohu whānui o te kaiwhakanao te ki taua tikanga me te paerewa:

• i te ako tīmatanga wae mahi wāhanga e rima tekau (Iu) ia taimaha tinana manokaramu, engari kaua e nui atu i te toru werohanga / infusions ia wiki;
• i roto i te ngaro o te neke kitea: 75 wae / kg i te wā kotahi, engari kahore mua atu i te kotahi marama i muri i tomokanga o maimoatanga;
• i roto i te āhuatanga makehe: 100-200 U / kg, tino piri ki mea hōtaka werohia (taahiraa hua - 25 waeine / marama);
• tiaki therapy: horopeta whakahaere i te tere i i roto i te whānuitanga hematocrit o 30-35 vol. %.

Ka rite ki whakaaturanga mahi, mo te auau te tikanga riro "paerewa" kotahi o 30-100 Iu / kg, e te nuinga o pei i te mutunga o te tātari. Ko te roanga ikeiketanga o i / v whaowhia - tetahi ki te e rua meneti; tikanga mō te tuku subcutaneous o te matū kaha whai te taua ture.

Whakarōpū o taea ngā pānga kōaro

I te tauhohenga o tauari kaiao mohiotia ki te aroaro o nga wae tarukino pūrongo "Epoetin Alfa" ā-ako te whai ake:

• taea ki te sioloto te tohu motuhake ki wheori rewharewha - whanoke nui, korekore, ngoikore, kirika, nui te mamae tahi / uaua;
• whakaaetia nga nehe o te ngakau me te toto pera - he hua koi i roto i te pēhanga toto, takawhita mārere;
• e kore e taea e tetahi te tau'a ore i te mōrea o te thrombocytosis (te mate, ahakoa te mea he pānga ko tino onge, engari, he mahi wehe ki pōauautanga nui);
• taea ki te whakaawe i te huri i te nui o te pāhare pāporo me te Phosphate i roto i te tinana kaiwhakahohe i roto i te pūnaha mimi he (taumata creatinine kihai i peia e whakanui i roto i wē toto).

I runga i te kiri, ko te hoki ritenga ētahi wā kitea pōreareatanga e te introduction o "Epoetin Alfa" faaineineraa. Tohutohu, i roto i ngā, korero o rashes, katoatia, angioedema. A he aha te ngā: ka subcutaneous werohia he nui teitei pakeke ōrau: i runga i toharite i te mano take, whakaaro, hoki e pā ana ki 4 wāhanga (ki runga i / i roto i infusions - 1.6 anake).

I runga i nga huringa ārai e e meinga mea taonga, e kore ngā mōhiohio pono (taa'eraa anake e ki te kaha whakahuatia i mua o te tarukino kaha ai te hanganga o paturopi).

E ai ki nga contraindications kaiwhakanao

I runga i te kōrero e whakaratohia ana i roto i te aratohu e pā ana, "Epoetin Alfa" (analogs pērā i "Binokrit" me "Eralfon" tenei faatura rite tata ki te taketake i roto i) Kaua e whakamahia ki te:

• pāngia ki te takawhita whakakeke;
• ite te manawanui hypersensitivity ki te kai;
• whakakitea tātari kë te rārangi pathologies toto tino;
• i tukua e te manawanui he whakaeke ngakau (e korero tatou e pā ana ki te mua tata);
• reira he take ki te whakapono e te tauwhatinga o te rere toto tonu i roto i te roro.

I roto i te mau parau te tahi atu, me mua te tīmatanga o te therapy i te whakamātautau hauora.

Ara

"Arepa Epoetin" (tradename te hanganga ai kia ōrite waihanga rerekē - hei tauira, rite taea he whakakapinga te whakaekea analogs "Aeprin", "Repoetin-SP", "Epokomb", "Eprex", etc ...) Me te whakamahi ki nui haere tūpato ki te iwi e mate ana i recurrent disorders ma'i / o te uaua piringa. Ko te pono rawa tenei ture, ki te tuhia kē he hītori rite te whakautu o te tinana ki te rōpū o etahi taero wāhanga o tauhohe takiri.

e kore e pokanoa te reira ki te maiteraa, me mo te mate kauti. Me tuatahi nako ki te tuu i roto i ngā take e pā ana ki te pēhanga toto me te takanga o pāhoahoa (antihypertensives - tetahi o nga fakatonutonu akoranga hauora e whai ake nei). Heoi, he mea whakahirahira anö ki te arotake me te āhua pono o toa rino (te aroaro o werohanga auau). A, no te mau ana i roto i rawaka ngā mahi e kore e kitea i roto i ngā o te pēhanga toto, whakaahuatia technique mutu hua pharmacological te.

E ti'a ia tatou mahara e te tākihi kore, mate pukupuku, me te HIV kei i runga i te rārangi o mate i roto i te akoranga o e, ki te whakamārama o te kukū hematocrit, i reira te mea he heke āhuatanga i roto i ngā taumata ferritin i wē toto. Hei faaiti nehe huihui ki te therapy whakauru whai wāhi matū hohe Fe-kei roto.

Tauira mō te pūtoto he mea tika ki te tango i 1 wa katoa 7 ra. Ano i roto i te whakarewatanga o nga marama e rua e hiahiatia ana te aroturuki i ia te wā o te tatau mōtepe. A mo te 5-10 ra i mua ki te pokanga, whakahaere he manawanui te matū kāri rongoā he āhuatanga antithrombotic.

E kore e te kaiwhakanao whakahaere tikanga i roto e taea te wāhanga o te tarukino pā etahi momo o te pukupuku, na e kore e kia mutu kitea o te manawanui noa i te mutunga o te wāhanga maimoatanga hohe.

Aha ki te mahi i roto i te take o te tuwhena rawa?

"Arepa Epoetin" (taurite-taero, rokohanga, mahi i roto i te tikanga ōrite) ki te tuwhena rawa mahi rite te hātepe whakaurua i roto i te tātai matū o recombinant erythropoietin i.e. whakaoho polycythemia taumata hematocrit me oscillations. Nā ki te kore o antidotes matarohia, etahi mehua motuhake mō te Taupāhohe o kai e kore e kawea ki waho - whakakorea tika tetahi rongoā wāhui.

e totó ko whakaae hāngai i roto i te wā o te whawhati tata, ina tohu he ki runga-rohe tohu o te pūtoto te tino riri ki te ora.

Taunekeneke ki Medicines

I roto i te whakahaere maha-atamira therapy matatini he tino nui ki te mahino te mau parau tumu o "whanonga pharmacological" "Epoetin Alfa" kaiwhakahohe (puka tuku, te whakaahuatanga i runga, e taea e rerekē, engari e kore e te huarahi o tenei tauhohenga matüora huri).

Ko te kupu, i roto i ngā, faitatau ki te whakataki o ngā hua toto he pānga pai i runga i te whakapai ake i te akiaki. Engari me mahara tatou e te waimehatanga o te otinga o tetahi ko inadmissible. Ko te tarukino he cyclosporin "uniana" mahi wehe ki whakaiti i kukū o te muri (te ōwehenga rōrahi tino arotau o te pota e whakaritea empirically).

Comments

Analysis o nga whakaaro whakaatu e whakatika te maha rawa o ngā pātai, ina tae mai te reira ki te kōwhiringa e wātea ana mō te whakaoti i te raruraru taua. Hei tauira, torutoru o nga tūroro matau i roto i te rerekētanga e e tango te wahi i waenganui i taua hua pharmacological, rite "Alfa epoetin" me "epoetin peta."

He aha te mea te rerekētanga - ngāwari ki te matau, ki te utu tatou whakarongo ki nga kōrero o taote. Ko te take i māngai te tauira hanganga o te erythropoietin tūturu e mekameka e rua, me te pānga e hiahiatia ana i runga i te pūnaha toto i rua. Manufacturers taua rongoa, no te mea o te rerekētanga i roto i te hangarau, ranei synthesize alpha-kongakonga peta ranei.

Ko te kōrero i runga i te faaineineraa ano, he tokomaha o te hunga e i ki te tamata i te reira mo koe, whakaatu e te tikanga ko reira tino whai hua, a i roto i ētahi wā motuhake, me te i te katoa mahuinga mo etahi kāwai o tūroro.