Inhibitors Cholinesterase: te whakamahi o te pharmacological

Kei te mohiotia te reira e kua maha synapses te pūnaha io. He tika ratou mo te tuku o ponana. Tenei tukanga tā e rave rahi momo o kaitakawaenga. I roto ia ratou, - .., acetylcholine, norepinephrine, a Kapa, serotonin, me ētahi atu kaitakawaenga (foaki) e hiahiatia ana mo te whakawhitinga o tohu i waenganui i neurons. Ano, e tika ana ki a ratou te kawea reira excitation inhibition musculature ranei. I roto i ngā pathologies o te mahi neurotransmitters io kia takahia ai. tupu tenei e tika ana ki ngā tukanga atrophic me degenerative i roto i te roro. I roto i enei take, te whakamahi i taero e hiahiatia ana mō te faananea- raa attenuating te tohu tuku ranei. E te rōpū pharmacological rite he inhibitors cholinesterase. E whakamahia ratou i roto i myasthenia, neuritis, Amyotrophic sclerosis lateral, te mate o Alzheimer, pathologies hinengaro.

Pānga o inhibitors cholinesterase

inhibitors Cholinesterase - he rongoā Kei te whānui e whakamahia i roto i te Neurology me te mate hinengaro. E wehea ratou ki te maha ngā rōpū, i ia o nei te mea e hāngai ana i roto i te take ngā. Ko te mahi o enei taero mahi mā te ārai cholinesterase. E wātea ana i roto i rua iwi hauora me te hunga e mate ana i te tini o nga mate tenei whākōkī. He mea tika ki te wahi i raro i te neurotransmitter - acetylcholine. Ka rite ki te hua o tona tuku mahi iti ki Matuorakouawai, me te waikawa ahetiki. I roto i ngā pathologies o te atrophy uho roro puta āta. Ka rite ki te hua, kia hinga etahi hanganga tino, tae atu i te pūnaha cholinergic. Haunga atrophy roro, arata'i tenei ki tukanga degenerative o autoimmune, hopuhopu, āhua viral. Nā ki te whakangaromanga o te karihi forebrain reira ko te kore korerotia o te neurotransmitter - acetylcholine. Ka rite ki te roa rite i taea kahore kaimahi o te taonga, he mea e tika ana ki te mahi i runga i te whākōkī e te whakangaro i te reira. Hoki tenei whakaaro, e whakamahia nga inhibitors cholinesterase. Ngā mihi ki a ratou, kia tohe mahi neurotransmitter mō te maha o nga tau.

inhibitors Cholinesterase: taero whakarōpū

He maha ngā momo o raau taero anticholinesterase. Whakaröpütia ratou rite ki te pānga pharmacological i runga i te whākōkī. Etahi o ratou e ārai cholinesterase tina heke, etahi - poto. Tohatoha 3 ngā rōpū medicaments. I roto ia ratou:

1. blockers Reversible. mahi ēnei inhibitors cholinesterase i runga kē postsynaptic. Ngā mihi ki a ratou, Kei te poto haukotia te whākōkī. Tenei rōpū ngā acridines me piperidine.
2. Psevdoneobratimye blockers cholinesterase. Ko to ratou tikanga o te mahi i roto i te taha ki te wahi onionovoy o te rāpoi ngota whākōkī. I tua atu, e taea ki te here ki te receptors acetylcholine ratou. Enei āhuatanga Ko te rōpū o carbamates.
3. inhibitors tina heke o te cholinesterase. Tenei rōpū o taero mohiotia rite organo-phosphates tikanga. Māngai o te medicament "Metrifonate".

Ko te rōpū o acridines ngā "rererangi kawe" raau taero, me "Velnakrin". Māngai carbamates - rongoā "rivastigmine", "Epistatigmin".

Tuhinga mo te whakamahi o inhibitors cholinesterase

E whakamahia inhibitors Cholinesterase ki te hamani uaua mate o te take mai pokapū, atrophy me disorders roro degenerative. I tua atu, e wātea ana i roto i te puka o pata etahi rongoa. E whakamahia ratou i te pēhanga intraocular faateiteihia - papahewa. Drugs e tautāwhi i cholinesterase reversible, tohua hoki te maimoatanga o te tupu, mate o Pick me Alzheimer o. Hiahia, ko te ki te hoatu rōpū piperidine, mai he whiriwhiri ratou me te whai iti pānga taha. I roto i nga tau tata nei, ka nui haere nga tohu mo te whakamahi o taero. Ko tenei e tika ana ki te ako atu taipitopito o ratou āhuatanga. Hoki mate i roto i nei te raau taero anticholinesterase whakaritea ngā myasthenia gravis, atony intestinal, Duchenne, Amyotrophic sclerosis lateral, pāpāngia o wahi takenga degenerative. E whakamahia inhibitors tina heke i roto i te take o te paihana.

Contraindications ki te whakamahi o te raau taero cholinesterase

e kore te rongoā i roto i tenei rōpū whakamahia i roto i disorders takiri, hyperkinesis o tetahi etiology. E contraindicated ano ratou i roto i te tūroro ki te kore te ngakau nui, huangō, thyrotoxicosis. Ko reira houhou ki te tango i anticholinesterases ki whewhe pekitīlia te rere, enteritis. e kore e whakaaturia rongoā ki nga wahine hapu, me te lactating.

inhibitors Cholinesterase: te kōwhiringa o raau taero mo te mate o Alzheimer

mate o Alzheimer - he atrophic CNS, i roto i nei i reira he mate wareware, tuakiri mate, me te tupu. Kei te ngana Scientists huri noa te ao ki te kitea he rongoa mo tenei mate. I pakeke ngawari me te āhua o te mate, ko te tarukino o whiriwhiri "donepezil". E pā ana te reira ki te inhibitor cholinesterase reversible, kua he pānga whiriwhiri. He rongoā e whakamahia ana mo te whakaaro o te therapy pathogenetic. E kore te mea ia e taea ki te whakaora rawa i te manawanui, engari pōturi te whanaketanga o ngā tohu mate o Alzheimer.