Nui haere aminotransferase Alanine - he tohu o ngā tukanga inflammatory me degenerative i roto i whēkau

aminotransferase Nā heke i NH2-rōpū ki te kaituku waikawa γ-amino ki te acceptor - waikawa α-amino waho te hanganga takawaenga o haukinia. Ko, te transamination (transamination: whakawhiti reversible o ngā rōpū amino ki keto waikawa) - he tukanga whakatuwheratia e rongonui pūtaiao Russian me Kritsman Braunstein.

waikawa amino (aspartic, glutamic me alanine) i roto i transamination tahuri ki te hāngai waikawa α-keto, e he wāhanga o te huringa waikawa tricarboxylic. I roto i to ratou hāora i roto i te huringa Krebs, he ratou he puna o te pūngao.

E mea faufaa i roto i te whakarato Transamination te huringa Urea aspartate.

Ahakoa te meka e kia kitea ai te tauhohe transamination me nga waikawa amino kakara: phenylalanine, tyrosine me te tryptophan - kua kitea he tono mahi i roto i te rongoā i te whakamāramatanga o te mahi o te aspartate me aminotransferase alanine. E whānui tohaina ēnei whākōkī i roto i te kopa o te tinana tangata.

aminotransferase Alanine nui haere i roto i ngā pūtau toto whero, me te he ono ngā wā teitei tona kukū whakaritea ki taua i roto i te serum toto. whakaritea te kukū rawa o te whākōkī kei roto i te kopa ate.

e kore ko te taua hoki nga kopa tinana tangata täkupu aminotransferase Alanine. Hei tauira mahi paru i roto i te kiko cardiac he 7.1 (E * 10-3 g kiko homogenate), he ate - 44, uaua kōhiwi - 4,8, whatukuhu - 19, kōateate - 1.2, 0.7, me tana pukapuka serum - 0,016. Ngā tikanga mō te faaotiraa o te mahi aminotransferase i roto i te serum e wehea ki e rua ngā rōpū: te koirä (colorimetric, te whakamahi i tikanga, e kore e rite rawa ki te pāmahana te mana Cuvette Ineaho taputapu) me nekeneke (spectrophotometric).

B6 Ko te huaora noa i roto i te whānuitanga o ngā kai. Heoi, kia mahara ai e i roto i te tukanga tunu whakangaromia (waiariki obrobka) te huaora te. Pyridoxine Ko te cofactor i te nuinga o whākōkī. Kukū pirodoksin-5-Phosphate i roto i te toto heke ki te tau. Na reira, ko te mahi o tenei whākōkī ko alanine aminotransferase, heke i roto i te iwi pakeke atu i 64 tau (e pā ana ki te 30%) atu i te hunga 46-63 tau te pakeke. Ko te kukū o te huaora B6 i roto i te toto serum take alanine aminotransferase.

Hei whakatau Kei te maha te āhua mahi o te ate whakamatauria taumata aminotransferase i roto i te toto o te manawanui. Ko te tika tenei matua ki te meka e taui i roto i to ratou mahi puta nui tere atu i te tahi atu tawhā taiwhanga. Whakakorenga (putanga) o te whākōkī ate i roto i te toto, ko te tohu o te cytolysis - whakangaromanga pūtau ranei rangirua o ratou uruhanga membrane. A, no te tātari i te huringa i roto i te mahi o whākōkī nui ki te whakatū i te wahi o te whakakorenga. Me koe ki te mohio ratou mahi i roto i ngā pūtau toto me te tinana hauora, te localization subcellular me pākia. Ko te kukū o te whākōkī - alanine nui haere, ngā i roto i ngā pūtau ate, reira, ara kino iti ki ratou e whakaoho te hua i roto i te mahi paru i roto i te toto. Homai te mahi o te paru te tātari mate o te ate (kakā, steatosis).

nui haere aminotransferase Alanine necrosis o te ate, me te parenchymal kakā. rēhita i te kukū iti o te paru i roto i kakā me te ma'ii'o. kia mea te reira e te hua i roto i te mahi aminotransferase i serum tīmata 3-8 ra i mua i te tīmatanga o te tohu haumanu matua o te mate, me te tae he mōrahi i roto i nga ra wawe o te whanaketanga o te tukanga pathological.

Ko te kupu, nui haere aminotransferase alanine: cirrhosis o te ate, jaundice, mate pukupuku ate, infarction myocardial, kore matau ngakau, hypoxia, ru, myositis, myocarditis, steatosis, pancreatin, waipiro ma'i.